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Global, regional, and national prevalence of adult overweight and obesity, 1990...

GBD 2021 Adult BMI; Ng, Marie; Gakidou, Emmanuela; Lo, Justin; Abate, Yohannes Habtegiorgis; Abbafati, Cristiana; Abbas, Nasir; Abbasian, Mohammadreza

Background Overweight and obesity is a global epidemic. Forecasting future trajectories of the epidemic is crucial for providing an evidence base for policy change. In this study, we examine the historical trends of the global, regional, and national prevalence of adult overweight and obesity from 1990 to 2021 and forecast the future trajectories to 2050. Methods Leveraging established methodology from the Glob...


Global, regional, and national age-specific progress towards the 2020 milestone...

GBD 2021 Tuberculosis Collaborators; Ledesma, Jorge R.; Ma, Jianing; Zhang, Meixin; Basting, Ann V.L.; Chu, Huong Thi; Vongpradith, Avina

Background: Global evaluations of the progress towards the WHO End TB Strategy 2020 interim milestones on mortality (35% reduction) and incidence (20% reduction) have not been age specific. We aimed to assess global, regional, and national-level burdens of and trends in tuberculosis and its risk factors across five separate age groups, from 1990 to 2021, and to report on age-specific progress between 2015 and 2...


Global burden and strength of evidence for 88 risk factors in 204 countries and...

GBD 2021 Risk Factors Collaborators; Brauer, Michael; Roth, Gregory A.; Aravkin, Aleksandr Y.; Zheng, Peng; Abate, Kalkidan Hassen

Background: Understanding the health consequences associated with exposure to risk factors is necessary to inform public health policy and practice. To systematically quantify the contributions of risk factor exposures to specific health outcomes, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 aims to provide comprehensive estimates of exposure levels, relative health risks, and attr...


Burden of disease scenarios for 204 countries and territories, 2022–2050: a for...

GBD 2021 Forecasting Collaborators; Vollset, Stein Emil; Ababneh, Hazim S.; Abate, Yohannes Habtegiorgis; Abbafati, Cristiana; Abbasgholizadeh, Rouzbeh

Background: Future trends in disease burden and drivers of health are of great interest to policy makers and the public at large. This information can be used for policy and long-term health investment, planning, and prioritisation. We have expanded and improved upon previous forecasts produced as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) and provide a reference forecast (the...


Global incidence, prevalence, years lived with disability (YLDs), disability-ad...

GBD 2021 Diseases and Injuries Collaborators; Ferrari, Alize J.; Santomauro, Damian Francesco; Aali, Amirali; Abate, Yohannes Habtegiorgis

Background: Detailed, comprehensive, and timely reporting on population health by underlying causes of disability and premature death is crucial to understanding and responding to complex patterns of disease and injury burden over time and across age groups, sexes, and locations. The availability of disease burden estimates can promote evidence-based interventions that enable public health researchers, policy m...


Global, regional, and national burden of disorders affecting the nervous system...

GBD 2021 Nervous System Disorders Collaborators; Steinmetz, Jaimie D.; Seeher, Katrin Maria; Schiess, Nicoline; Nichols, Emma; Cao, Bochen

Background: Disorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditions in 2015 and 2016, but these analyses did not include neurode...


Global, regional, and national burden of diabetes from 1990 to 2021, with proje...

Ong, Kanyin Liane; Stafford, Lauryn K.; McLaughlin, Susan A.; Boyko, Edward J.; Vollset, Stein Emil; Smith, Amanda E.; Dalton, Bronte E.; Duprey, Joe

Diabetes is one of the leading causes of death and disability worldwide, and affects people regardless of country, age group, or sex. Using the most recent evidentiary and analytical framework from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD), we produced location-specific, age-specific, and sex-specific estimates of diabetes prevalence and burden from 1990 to 2021, the proportion of ty...


Global, regional, and national incidence of six major immune-mediated inflammat...

GBD 2019 IMID Collaborators; Wu, Dongze; Jin, Yingzhao; Xing, Yuhan; Abate, Melsew Dagne; Abbasian, Mohammadreza; Abbasi-Kangevari, Mohsen

Background: The causes for immune-mediated inflammatory diseases (IMIDs) are diverse and the incidence trends of IMIDs from specific causes are rarely studied. The study aims to investigate the pattern and trend of IMIDs from 1990 to 2019. Methods: We collected detailed information on six major causes of IMIDs, including asthma, inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, psoriasis, an...


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