6 documents found, page 1 of 1
Models of care and associated targeted implementation strategies for cancer sur...
Prue, Gillian; Czamanski-Cohen, Johanna; Kassianos, Angelos P; Pilleron, Sophie; Ladas, Aristea; Can, Aysun Akcakaya; Roldán-Jiménez, Cristina<jats:sec><jats:title>Introduction</jats:title><jats:p>Cancer and its treatments can lead to a wide range of side-effects that can persist long after treatments have ended. Across Europe, survivorship care is traditionally hospital-based specialist-led follow-up, leading to gaps in supportive care. Improved screening, diagnosis and treatment increase survival rates. With more individuals living with, through an...
LOCO-REGIONAL APPROACH IN THE TREATMENT OF HEPATOCELLULAR CARCINOMA
Alves Vaz, Ana Luísa; Martins, Rui Miguel; Tralhão, José GuilhermeHepatocellular carcinoma ranks 5th in terms of the most frequent neoplasms, currently constituting one of the main causes of death from cancer. The vast investigation and growing knowledge on the mechanisms of this neoplasia, allowed the development of a set of therapies, which can be used alone or combined, thus contributing to a change in the treatment paradigm for these patients. Liver resection is the metho...
Evaluation of bioenergetic and mitochondrial function in liver transplantation
Martins, Rui Miguel; Teodoro, João S.; Furtado, Emanuel; Rolo, Anabela Pinto; Palmeira, Carlos Marques; Tralhão, José GuilhermeBackground/Aims: We measured changes in mitochondrial function and bioenergetics that occur during ischemia/ reperfusion in fresh liver samples of patients undergoing liver transplantation. These variations correlated with markers of liver function and clinical outcome. Ischemia/reperfusion injury related to liver transplantation affects mitochondrial function and bioenergetics. Experimental studies were conduc...
Mild hypothermia during the reperfusion phase protects mitochondrial bioenerget...
Martins, Rui Miguel; Teodoro, João S.; Furtado, Emanuel; Oliveira, Rui Caetano; Tralhão, José Guilherme; Rolo, Anabela Pinto; Palmeira, Carlos MarquesThe organ preservation paradigm has changed following the development of new ways to preserve organs. The use of machine perfusion to preserve organs appears to have several advantages compared with conventional static cold storage. For liver transplants, the temperature control provided by machine perfusion improves organ preservation. In this experimental study, we measured the effects of different temperatur...
Recent insights into mitochondrial targeting strategies in liver transplantation
Martins, Rui Miguel; Teodoro, João Soeiro; Furtado, Emanuel; Rolo, Anabela Pinto; Palmeira, Carlos Marques; Tralhão, José GuilhermeIschemia/reperfusion (I/R) injury in liver transplantation can disrupt the normal activity of mitochondria in the hepatic parenchyma. This potential dysfunction of mitochondria after I/R injury could be responsible for the initial poor graft function or primary nonfunction observed after liver transplantation. Thus, determining the mechanisms that lead to human hepatic mitochondrial dysfunction might contribute...
Addition of Berberine to Preservation Solution in an Animal Model of Ex Vivo Li...
Martins, Rui Miguel; Rolo, Anabela Pinto; Teodoro, João Soeiro; Furtado, Emanuel; Oliveira, Rui Caetano; Tralhão, José GuilhermeLiver transplantation is a therapeutic regimen to treat patients with non-malignant end-stage liver diseases and malignant tumors of hepatic origin. The ischemia/reperfusion (I/R) injury in liver transplantation is associated with disruption of mitochondrial function in the hepatic parenchyma. Several studies have been conducted in animal models to identify pharmacological therapeutic strategies to minimize the...