17 documents found, page 1 of 2
Kinetics of radium-223 and its effects on survival, proliferation and DNA damag...
Marques, IA; Abrantes, AM; Pires, AS; Neves, AR; Caramelo, FJ; Rodrigues, T; Matafome, P; Tavares-da-Silva, E; Gonçalves, AC; Pereira, CC; Teixeira, JPBackground Metastatic castration-resistant prostate cancer (mCRPC) is associated with a very unfavorable prognosis. At this advanced stage of the disease, there are several therapeutic strategies approved in recent times, being one of them Radium-223 dichloride (Radium-223). However, its mechanisms of action and the process that conducts to cell death are not fully understood. Given this, our main goal is to ch...
Evaluation of the efficacy of dentin hypersensitivity treatments - a systematic...
Marto, CM; Baptista Paula, A; Nunes, T; Pimenta, M; Abrantes, AM; Pires, AS; Laranjo, M; Coelho, A; Donato, H; Botelho, MF; Marques Ferreira, MOBJECTIVES: To compare the treatments used to treat dentin hypersensitivity (DH), based on its efficacy and effect duration. METHODS: Medline/PubMed, Cochrane Library, EMBASE, and ClinicalTrials were searched for articles published between January 1st , 2008 and November 14th , 2018, in English, Portuguese or Spanish, reporting clinical trials, completed and with results. This systematic review protocol was reg...
Endometrial Cancer Spheres Show Cancer Stem Cells Phenotype and Preference for ...
Carvalho, MJ; Laranjo, M; Abrantes, AM; Casalta-Lopes, J; Sarmento-Santos, D; Costa, T; Serambeque, B; Almeida, N; Gonçalves, T; Mamede, CThis study aimed to characterize endometrial cancer regarding cancer stem cells (CSC) markers, regulatory and differentiation pathways, tumorigenicity and glucose metabolism. Endometrial cancer cell line ECC1 was submitted to sphere forming protocols. The first spheres generation (ES1) was cultured in adherent conditions (G1). This procedure was repeated and was obtained generations of spheres (ES1, ES2 and ES3...
Array-comparative genomic hybridization as a novel high-throughput approach in ...
Neves, AR; Abrantes, AM; Ribeiro, IP; Marques, IA; Marques, V; Tavares da Silva, E; Carreira, IM; Figueiredo, A; Botelho, MF
The future of selective oncology therapy applied to urological tumors - plasma ...
Tavares da Silva, E; Almeida-Ferreira, C; Silva-Teixeira, R; Eliseu, M; Laranjo, M; Marques, I; Neves, R; Abrantes, AM; Caramelo, F; Figueiredo, A
The effect of cold atmospheric plasma in bladder cancer cell
Tavares da Silva, E; Neves, AR; Abrantes, AM; Silva-Teixeira, R; Figueiredo, A; Botelho, MF
Selective ablating urologic cancers with cold atmospheric plasma
Almeida-Ferreira, C; Tavares da Silva, E; Silva-Teixeira, R; Laranjo, M; Marques, I; Neves, R; Abrantes, AM; Caramelo, F; Figueiredo, A; Botelho, MF
Oxidative Stress, DNA, Cell Cycle/Cell Cycle Associated Proteins and Multidrug ...
Mamede, AC; Guerra, S; Laranjo, M; Santos, K; Carvalho, MJ; Carvalheiro, T; Moura, P; Paiva, A; Abrantes, AM; Maia, CJ; Botelho, MFThe anticancer effects of human amniotic membrane (hAM) have been studied over the last decade. However, the action mechanisms responsible for these effects are not fully understood until now. Previously results reported by our team proved that hAM is able to induce cytotoxicity and cell death in hepatocellular carcinoma (HCC), a worldwide high incident and mortal cancer. Therefore, this experimental study aime...
Impact of splenic artery ligation after major hepatectomy on liver function, re...
Carrapita, J; Abrantes, AM; Campelos, S; Gonçalves, AC; Cardoso, D; Sarmento-Ribeiro, AB; Rocha, C; Santos, JN; Botelho, MF; Tralhão, JG; Farges, OIt was reported that prevention of acute portal overpressure in small-for-size livers by inflow modulation results in a better postoperative outcome. The aim is to investigate the impact of portal blood flow reduction by splenic artery ligation after major hepatectomy in a murine model. Forty-eight rats were subjected to an 85% hepatectomy or 85% hepatectomy and splenic artery ligation. Both groups were evaluat...
Influence of P53 on the radiotherapy response of hepatocellular carcinoma
Gomes, AR; Abrantes, AM; Brito, AF; Laranjo, M; Casalta-Lopes, JE; Gonçalves, AC; Sarmento-Ribeiro, AB; Botelho, MF; Tralhão, JGHepatocellular carcinoma (HCC) is one of the most common cancers worldwide, and it has a poor prognosis and few therapeutic options. Radiotherapy is one of the most effective forms of cancer treatment, and P53 protein is one of the key molecules determining how a cell responds to radiotherapy. The aim of this study was to determine the therapeutic efficacy of iodine-131 in three human HCC cell lines.