15 documents found, page 1 of 2
Microleakage Evaluation of Temporary Restorations Used in Endodontic Treatment-...
Paulo, Siri; Abrantes, Ana M.; Xavier, Mariana; Brito, Ana Filipa; Teixo, Ricardo; Coelho, Ana; Paula, Anabela; Carrilho, Eunice(1) Background: Coronal microleakage can lead to endodontic treatment failure. This study aimed to compare the sealing ability of different temporary restorative materials used during endodontic treatment. (2) Methods: Eighty sheep incisors were collected, uniformized in length, and access cavities were performed, except for in the negative control group, where the teeth were left intact. The teeth were divided...
Metabolomic Profiling in Lung Cancer: A Systematic Review
Madama, Daniela; Martins, Rosana; Pires, Ana S.; Botelho, Maria F.; Alves, Marco G.; Abrantes, Ana M.; Cordeiro, Carlos R.Lung cancer continues to be a significant burden worldwide and remains the leading cause of cancer-associated mortality. Two considerable challenges posed by this disease are the diagnosis of 61% of patients in advanced stages and the reduced five-year survival rate of around 4%. Noninvasively collected samples are gaining significant interest as new areas of knowledge are being sought and opened up. Metabolomi...
Cold Atmospheric Plasma, a Novel Approach against Bladder Cancer, with Higher S...
Silva, Edgar Tavares da; Pereira, Eurico; Pires, Ana S.; Neves, Ana Rita M.; Guilherme, Catarina Braz; Marques, Inês A.; Abrantes, Ana M.Antitumor therapies based on Cold Atmospheric Plasma (CAP) are an emerging medical field. In this work, we evaluated CAP effects on bladder cancer. Two bladder cancer cell lines were used, HT-1376 (stage III) and TCCSUP (stage IV). Cell proliferation assays were performed evaluating metabolic activity (MTT assay) and protein content (SRB assay). Cell viability, cell cycle, and mitochondrial membrane potential (...
Evaluation of dentinogenesis inducer biomaterials: an in vivo study
Paula, Anabela B.; Laranjo, Mafalda; Marto, Carlos Miguel; Paulo, Siri Folques Vicente de; Abrantes, Ana M.; Fernandes, Bruno; Casalta-Lopes, JoãoWhen exposure of the pulp to external environment occurs, reparative dentinogenesis can be induced by direct pulp capping to maintain pulp tissue vitality and function. These clinical situations require the use of materials that induce dentin repair and, subsequently, formation of a mineralized tissue. Objective: This work aims to assess the effect of tricalcium silicate cements and mineral trioxide aggregate c...
Direct Pulp Capping: Which is the Most Effective Biomaterial? A Retrospective C...
Paula, Anabela; Carrilho, Eunice; Laranjo, Mafalda; Abrantes, Ana M.; Casalta-Lopes, João; Botelho, Maria Filomena; Marto, Carlos Miguel(1) Background: Recently, tricalcium silicate cements, such as Biodentine™, have emerged. This biomaterial has a calcium hydroxide base and characteristics like mineral aggregate trioxide cements, but has tightening times that are substantially more suitable for their application and other clinical advantages. (2) Methods: A retrospective clinical study was conducted with 20 patients, which included a clinical ...
Synthetic Calcium Phosphate Ceramics as a Potential Treatment for Bisphosphonat...
Paulo, Siri; Laranjo, Mafalda; Abrantes, Ana M.; Casalta-Lopes, João; Santos, Kathleen; Gonçalves, Ana C.; Paula, Anabela Baptista; Marto, Carlos Miguel(1) Background: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is one of the most often seen side effects in patients treated with nitrogen-containing bisphosphonates (BPs), a post-surgical non-healing wound condition. Since calcium phosphate (CP) compounds are able to adsorb zoledronate (ZOL) when used as a drug delivery vehicle, we aimed to verify if these ceramics might have a potential protective e...
Diabetes mellitus and prostate cancer metabolism: Is there a relationship?
Antunes, Hugo Pontes; Teixo, Ricardo; Carvalho, João André; Eliseu, Miguel; Marques, Inês; Mamede, Ana; Neves, Rita; Oliveira, RuiObjective: Our aim was to evaluate the effects of glucose levels and diabetes mellitus in prostate cancer (PCa) biology. Materials and methods: Two PCa cell lines (LNCap and PC3) were cultured in RPMI medium with different glucose concentrations [5mM (LG) and 25mM (HG)]. Expressions of androgen receptor, Her2/neu and glucose transporters (GLUT1, 3, 5 and 12) were evaluated by flow cytometry. Proliferation rate ...
Ascorbic Acid Chemosensitizes Colorectal Cancer Cells and Synergistically Inhib...
Pires, Ana S.; Marques, Cláudia R.; Encarnação, João C.; Abrantes, Ana M.; Marques, Inês A.; Laranjo, Mafalda; Oliveira, Rui; Lopes, João E. CasaltaColorectal cancer (CRC) is continuously classified as one of the most incidental and mortal types of cancer worldwide. The positive outcomes of the conventional chemotherapy are frequently associated with high toxicity, which often leads to the suspension of the treatment. Growing evidences consider the use of pharmacological concentrations of ascorbic acid (AA), better known as vitamin C, in the treatment of c...
Doping β-TCP as a Strategy for Enhancing the Regenerative Potential of Composit...
Ferreira, Manuel M.; Brito, Ana F.; Brazete, Daniela; Pereira, Inês C.; Carrilho, Eunice; Abrantes, Ana M.; Pires, Ana S.; Aguiar, Maria JThe present work aims at evaluating the potential gains derived from partially replacing calcium in resorbable β-tricalcium phosphate (β-TCP) by two different molar percentages of strontium (5, 10) and zinc (1, 2), concomitantly with a fixed molar percentage (0.5) of manganese. Synthetic granular composite bone filling grafts consisting of doped β-TCP and an alkali-free bioactive glass were prepared and implant...
Tissular growth factors profile after teduglutide administration on an animal m...
Costa, Beatriz P.; Gonçalves, Ana C.; Abrantes, Ana M.; Alves, Raquel; Matafome, Paulo N.; Seiça, Raquel; Ribeiro, Ana B. Sarmento; Botelho, M. FilomenaBackground: Teduglutide is an enterotrophic analogue of glucagon-like peptide-2, with an indirect and poorly understood mechanism of action, approved for the rehabilitation of short-bowel syndrome. This study aims to analyze the response of tissue growth factors to surgical injury and teduglutide administration on an animal model of intestinal anastomosis. Methods: Wistar rats (n = 59) were distributed into fou...