2 documents found, page 1 of 1
Behind a Paralyzing Pandemic: Renal Cortical Necrosis
Furtado,Teresa; Abrantes,Catarina; Domingues,Patrícia; Natário,Ana; Góis,Mário; Sousa,HelenaABSTRACT Renal cortical necrosis (RCN) is a rare cause of acute kidney injury (AKI) in developed countries. Drugs, especially non-steroidal antiinflammatory drugs, (NSAIDs) are very rarely described in the literature to cause cortical necrosis. It is characterized by confluent necrosis of the entire cortex apart from a thin rim of viable tissue in the subcapsular, juxtaglomerular areas, and medulla. Although th...
Alagille Syndrome: An ultrafiltration dilema
Abrantes,Catarina; Furtado,Teresa; Domingues,Patrícia; Valério,Patrícia; Felgueiras,Joana; Assunção,José; Vaz,ÁlvaroABSTRACT Alagille syndrome (AGLS) is a rare genetic disorder caused by mutations in the Notch signaling pathway. Multiple organ dysfunction is frequent despite phenotypic variability. We report the case of an AGLS patient with right heart failure and persistent fluid overload who started peritoneal ultrafiltration, without initial benefit. Possible pathophysiological mechanisms related to the underlying genetic...