Severe food restriction (FR) is associated with blood pressure (BP) and cardiovascular dysfunction. The renin-angiotensin system (RAS) regulates BP and its dysregulation contributes to impaired cardiovascular function. Female Fischer rats were maintained on a control (CT) or severe FR (40% of CT) diet for 14 days. In response to severe FR, BP allostasis was achieved by up-regulating circulating Ang-[1–8] by 1.3...
The amygdala has been associated with a variety of functions linked to physiological, behavioral and endocrine responses during emotional situations. This brain region is comprised of multiple sub-nuclei. These subnuclei belong to the same structure, but may be involved in different functions, thereby making the study of each sub-nuclei important. Yet, the involvement of the basomedial amygdala (BMA) in the reg...
Programa de Pós-Graduação em Ciências Biológicas. Núcleo de Pesquisas em Ciências Biológicas, Pró-Reitoria de Pesquisa de Pós Graduação, Universidade Federal de Ouro Preto.; Estudos anteriores de nosso laboratório demonstraram que a obesidade, induzida por uma dieta hiperlipídica, potencializa a resposta cardiovascular produzida pelo estresse de jato de ar em ratos. Esta resposta aumentada é devido a uma reduçã...
Aims: Weevaluated the effect of food restriction (FR) on the various reflexes involved in short termcardiovascular regulation; we also evaluated the contribution of the sympathetic nervous systemand of the plasmatic nitric oxide (NO) in the development of the counterregulatory cardiovascular changes triggered by FR. Main methods: Female rats were subjected to FR for 14 days, and after this period biochemical me...
Rats fed a high-fat diet (HFD) present an exaggerated endocrine response to stress conditions, which, like obesity, show a high correlation with cardiovascular diseases. Meanwhile the GABAergic neurotransmission within the dorsomedial hypothalamus (DMH) is involved in the regulation of the physiological responses during emotional stress. Here we evaluated the influence of obesity, induced by a HFD, on the cardi...
O hipotálamo dorsomedial (DMH) está envolvido na mediação das respostas funcionais durante o estresse (e.g.: nas alterações cardiovasculares em ratos submetidos ao estresse por jato de ar ou isolamento social). Estudos sugerem que ratos alimentados com uma dieta hiperlipídica (DH) apresentam uma resposta exagerada em condições de estresse e que este, assim como a obesidade apresenta forte associação com doenças...