2 documents found, page 1 of 1
WDR60-mediated dynein-2 loading into cilia powers retrograde IFT and transition...
De-Castro, ARG; Rodrigues, DRM; De-Castro, MJG; Vieira, N; Vieira, C; Carvalho, AX; Gassmann, R; Abreu, CMC; Dantas, TThe dynein-2 motor complex drives retrograde intraflagellar transport (IFT), playing a pivotal role in the assembly and functions of cilia. However, the mechanisms that regulate dynein-2 motility remain poorly understood. Here, we identify the Caenorhabditis elegans WDR60 homologue, WDR-60, and dissect the roles of this intermediate chain using genome editing and live imaging of endogenous dynein-2/IFT componen...
Coping with centriole loss: pericentriolar material maintenance after centriole...
Abreu, CMC; Dantas, TJShortly after the onset of ciliogenesis in Caenorhabditis elegans sensory neurons, the centrioles/basal bodies undergo degeneration. The fate of the pericentriolar material (PCM) that was associated with those centrioles has, however, remained unknown. Two recent studies by the Dammermann and the Feldman groups now show that not only does the PCM persist at the ciliary base, it also continues to assemble in the...