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Dynamics of a Dual SARS-CoV-2 Lineage Co-Infection on a Prolonged Viral Sheddin...

Pedro, N; Silva, CN; Magalhães, AC; Cavadas, B; Rocha, AM; Moreira, AC; Gomes, MS; Silva, D; Sobrinho-Simões, J; Ramos, A; Cardoso, MJ; Filipe, R

A few molecularly proven severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cases of symptomatic reinfection are currently known worldwide, with a resolved first infection followed by a second infection after a 48 to 142-day intervening period. We report a multiple-component study of a clinically severe and prolonged viral shedding coronavirus disease 2019 (COVID-19) case in a 17-year-old Portuguese f...


Dynamics of a dual sars-cov-2 lineage co-infection on a prolonged viral sheddin...

Pedro, N; Silva, CN; Magalhães, AC; Cavadas, B; Rocha, AM; Moreira, AC; Gomes, MS; Silva, D; Sobrinho-Simões, J; Ramos, A; Cardoso, MJ; Filipe, R

A few molecularly proven severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cases of symptomatic reinfection are currently known worldwide, with a resolved first infection followed by a second infection after a 48 to 142-day intervening period. We report a multiplecomponent study of a clinically severe and prolonged viral shedding coronavirus disease 2019 (COVID-19) case in a 17-year-old Portuguese fe...


Aortic Prosthesis-Associated MDR Pseudomonas Infections as a Diagnostic and The...

Filipe, R; Ceia, F; Carvalho, AC; Tavares, MF; Teixeira, J; Sarmento, A

Endovascular prostheses are used to treat life-threatening conditions such as ruptured aortic aneurysms. Prosthetic infection cause significant morbidity and mortality, posing important diagnostic and therapeutic challenges. It is particularly difficult to diagnose and, in the era of multidrug resistance (MDR), these type of infections may become even more difficult to treat. Herein, we reported a case of a sec...


Central nervous system varicella zoster vasculopathy in an immunocompromised pa...

Guedes, M; Filipe, R; Costa, A; Soares, C; Sarmento, A; Tavares, M

Central nervous system (CNS) vasculopathy associated with Varicella Zoster Virus (VZV) infection, usually manifesting as stroke due to ischemic lesions by involvement of small arteries, is frequently misdiagnosed. Immunocompromised patients have a particularly higher risk of severe disease and also CNS involvement during or following VZV presentations. We report a case of an 84-year-old man, with myelodysplasti...


Collagen Type IV-Related Nephropathies in Portugal: Pathogenic COL4A5 Mutations...

Nabais Sá, MJ; Sampaio, S; Oliveira, A; Alves, S; Moura, CP; Silva, SE; Castro, R; Araújo, JA; Rodrigues, M; Neves, F; Seabra, J; Soares, C; Gaspar, MA

Alport syndrome (AS) is caused by pathogenic mutations in the genes encoding α3, α4 or α5 chains of collagen IV (COL4A3/COL4A4/COL4A5), resulting in hematuria, chronic renal failure (CRF), sensorineural hearing loss (SNHL) and ocular abnormalities. Mutations in the X-linked COL4A5 gene have been identified in 85% of the families (XLAS). In this study, 22 of 60 probands (37%) of unrelated Portuguese families, wi...


Hard-to-heal venous-lymphatic leg ulcers: a special case

Silva, JA; Filipe, R; Esteves, M; Andriessen, A

In the treatment of this 56-year-old male, the aim was to attend to his multiple pathologies, reducing his venous-lymphatic oedema on both legs, closing the extended ulcers and improving his quality of life. The patient received treatment in a community-based wound healing clinic. After various local therapies were not successful, the wounds were cleansed with saline and covered with a biocellulose dressing (BW...


Patient caring by wound managing on Hospital Fernando Fonseca

Campos, A; Oliveira, D; Simões, Z; Baptista, M; Figueiredo, E; Filipe, R; Fernandes, J


Kidney transplantation with corticosteroid-free maintenance immunosuppression: ...

Filipe, R; Mota, A; Alves, R; Bastos, C; Macário, F; Figueiredo, A; Roseiro, A; Parada, B; Sá, H; Nunes, P; Bastos, M

The purpose of this study was to assess the impact of a corticosteroid-free maintenance immunosuppression on graft survival in kidney transplantation. We analyzed 79 patients who were transplanted between June 1, 2006 and May 31, 2007. We excluded hyperimmunized patients, second transplantations, living donors, and black recipients. Patients underwent induction with thymoglobulin or basiliximab, followed by tre...


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