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Host- and microbe-related risk factors for and pathophysiology of fatal Rickett...

Sousa, R; França, A; Nóbrega, SD; Belo, A; Amaro, M; Abreu, T; Poças, J; Proença, P; Vaz, J; Torgal, J; Bacellar, F; Ismail, N; Walker, D

BACKGROUND: The pathophysiologic mechanisms that determine the severity of Mediterranean spotted fever (MSF) and the host-related and microbe-related risk factors for a fatal outcome are incompletely understood. METHODS: This prospective study used univariate and multivariate analyses to determine the risk factors for a fatal outcome for 140 patients with Rickettsia conorii infection admitted to 13 Portuguese h...


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