15 documents found, page 1 of 2
The association of collaterals with myocardial ischemia and viability in chroni...
Leite, Luís; Campos, Gustavo; Silva, Rodolfo; Jorge, Elisabete; Oliveira-Santos, Manuel; Gomes, Andreia; Gonçalves, Lino; Castelo-Branco, MiguelCollateral development in chronic total occlusions (CTO) is crucial to perfuse the distal myocardium and its angiographic evaluation is frequently used to assess the need for revascularization. We aimed to analyse the association between the presence of ischemia and hibernating myocardium, evaluated by cardiac [13 N]NH3/2-[18 F]FDG PET-CT, and the angiographic characterization of the collateral circulation. Pro...
Antibody and Nanobody Radiolabeling with Copper-64: Solid vs. Liquid Target App...
Hrynchak, Ivanna; Cocioabă, Diana; Fonseca, Alexandra I.; Leonte, Radu; Carmo, Sérgio do; Cornoiu, Roxana; Falcão, Amílcar; Niculae, DanaAntibody and nanobody-based copper-64 radiopharmaceuticals are increasingly being proposed as theranostic tools in multiple human diseases. While the production of copper-64 using solid targets has been established for many years, its use is limited due to the complexity of solid target systems, which are available in only a few cyclotrons worldwide. In contrast, liquid targets, available in virtually in all cy...
Textural properties of microglial activation in Alzheimer's disease as measured...
Lapo Pais, Marta; Jorge, Lília; Martins, Ricardo; Canário, Nádia; Xavier, Ana Carolina; Bernardes, Rui; Abrunhosa, Antero; Santana, IsabelAlzheimer's disease is the most common form of dementia worldwide, accounting for 60-70% of diagnosed cases. According to the current understanding of molecular pathogenesis, the main hallmarks of this disease are the abnormal accumulation of amyloid plaques and neurofibrillary tangles. Therefore, biomarkers reflecting these underlying biological mechanisms are recognized as valid tools for an early diagnosis o...
An RPC-PET brain scanner demonstrator: first results
Fonte, Paulo; Lopes, Luís; Alves, Rui; Carolino, Nuno; Crespo, Paulo; Couceiro, Miguel; Cunha, Orlando; Dias, Nuno; Ferreira, Nuno C.; Fetal, SuseteWe present first results from a Positron Emission Tomography (PET) scanner demonstrator based on Resistive Plate Chambers and specialized for brain imaging. The device features a 30 cm wide cubic field-of-view and each detector comprises 40 gas gaps with 3D location of the interaction point of the photon. Besides other imagery, we show that the reconstructed image resolution, as evaluated by a hot-rod phantom, ...
Nucleolin Overexpression Predicts Patient Prognosis While Providing a Framework...
Fernandes, Ângela Valério; Fonseca, Nuno A.; Gonçalves, Nélio; Cruz, Ana F.; Pereira, Marta I.; Gregório, Ana C.; Moura, Vera; Ladeirinha, Ana F.Notwithstanding the advances in the treatment of lung cancer with immune checkpoint inhibitors, the high percentage of non-responders supports the development of novel anticancer treatments. Herein, the expression of the onco-target nucleolin in patient-derived pulmonary carcinomas was characterized, along with the assessment of its potential as a therapeutic target. The clinical prognostic value of nucleolin f...
Improved Characteristics of RANKL Immuno-PET Imaging Using Radiolabeled Antibod...
Dewulf, Jonatan; Hrynchak, Ivanna; Geudens, Sarah; Pintelon, Isabel; Vangestel, Christel; Sereno, José; van Dam, Peter A; Abrunhosa, AnteroRANKL expression in the tumor microenvironment has been identified as a biomarker of immune suppression, negating the effect of some cancer immunotherapies. Previously we had developed a radiotracer based on the FDA-approved RANKL-specific antibody denosumab, [89Zr]Zr-DFO-denosumab, enabling successful immuno-PET imaging. Radiolabeled denosumab, however, showed long blood circulation and delayed tumor uptake, p...
Combined Structural MR and Diffusion Tensor Imaging Classify the Presence of Al...
Agostinho, Daniel; Caramelo, Francisco; Moreira, Ana Paula; Santana, Isabel; Abrunhosa, Antero; Castelo Branco, MiguelBackground: In recent years, classification frameworks using imaging data have shown that multimodal classification methods perform favorably over the use of a single imaging modality for the diagnosis of Alzheimer's Disease. The currently used clinical approach often emphasizes the use of qualitative MRI and/or PET data for clinical diagnosis. Based on the hypothesis that classification of isolated imaging mod...
A link between synaptic plasticity and reorganization of brain activity in Park...
Rebelo, Diliana; Oliveira, Francisco; Abrunhosa, Antero; Januário, Cristina; Lemos, João; Castelo-Branco, MiguelThe link between synaptic plasticity and reorganization of brain activity in health and disease remains a scientific challenge. We examined this question in Parkinson's disease (PD) where functional up-regulation of postsynaptic D2 receptors has been documented while its significance at the neural activity level has never been identified. We investigated cortico-subcortical plasticity in PD using the oculomotor...
A positron-emission tomography (PET)/magnetic resonance imaging (MRI) platform ...
Banerjee, Arnab; Alves, Vitor; Rondão, Tiago; Sereno, José; Neves, Ângela; Lino, Miguel; Ribeiro, Andreia; Abrunhosa, Antero; Ferreira, LinoProject TRoMBONE grant number 748583 under the Horizon 2020 program of European commission, “StrokeTherapy” co-promoted by Stemlab, Rovisco Pais and Universidade de Coimbra, POCI-01 -0247- FEDER-003386), EC project ERAatUC (Ref:669088) and FCT project (Ref no. POCI-01-0145-FEDER-029919).
Automated Purification of Radiometals Produced by Liquid Targets
Alves, Vítor H. P.; Carmo, Sérgio do; Alves, Francisco; Abrunhosa, AnteroAn automated process for the production and purification of radiometals produced by irradiating liquid targets in a medical cyclotron, using a commercially available module, has been developed. The method is suitable for the production and purification of radiometals such as 68Ga, 64Cu and 61Cu through irradiation of liquid targets and is important for producing high specific activity radioisotopes with a subst...