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Cytinus hypocistis (L.) L. extract effects in an animal model of papillomavirus...

Medeiros, C; Silva, AR; Ferreira, T; Barros, L; Neuparth, MJ; Peixoto, F; Bastos, MMSM; Medeiros, R; Gil da Costa, RM; Pires, MJ; Faustino-Rocha, Ana I

nfections with certain types of papillomavirus, such as the human papillomavirus 16 (HPV16), are associated with the development of preneoplastic lesions and cancers of the anogenital, and head and neck regions. Cytinus hypocistis (L.) L. extracts are composed of substances presenting antiproliferative, antioxidant, anti-inflammatory and antibacterial properties, which might be promising as new therapeutic comp...


Data quality review of the Brazilian nosocomial infections surveillance system

Silva, AR; Hoffmann, NG; Fernandez-Llimos, F; Lima, EC

Background: Surveillance of healthcare-associated infections (HAIs) is an essential component of hospital infection prevention and control systems. We aimed to assess the quality of the data compiled by the Brazilian HAI Surveillance System from pediatric (PICUs) and neonatal intensive care units (NICUs), between 2012 and 2021. Methods: Data Quality Review, including adherence, completeness, internal consistenc...


An anti-inflammatory and low fermentable oligo, di, and monosaccharides and pol...

Silva, AR; Bernardo, A; de Mesquita, MF; Vaz-Patto, J; Moreira, Pedro; Silva, ML; Padrão, Patrícia

Background: Fibromyalgia (FM) has been associated with dysbiosis and low-grade inflammation. Studies have reported that diet influences clinical features in FM. Objective: To evaluate the effect of an anti-inflammatory and low fermentable oligo, di, and monosaccharides and polyols (FODMAP) diet on clinical outcomes of patients with FM. Methods: This two arms Randomized Controlled Trial (NCT04007705) included 46...


HIV-1-Transmitted Drug Resistance and Transmission Clusters in Newly Diagnosed ...

Pingarilho, M; Pimentel, V; Miranda, M; Silva, AR; Diniz, A; Ascenção, B; Piñeiro, C; Koch, C; Rodrigues, C; Caldas, C; Morais, C; Faria, D

Objective: To describe and analyze transmitted drug resistance (TDR) between 2014 and 2019 in newly infected patients with HIV-1 in Portugal and to characterize its transmission networks. Methods: Clinical, socioepidemiological, and risk behavior data were collected from 820 newly diagnosed patients in Portugal between September 2014 and December 2019. The sequences obtained from drug resistance testing were us...


A study protocol for a randomized controlled trial of an anti-inflammatory nutr...

Silva, AR; Bernardo, A; de Mesquita, MF; Patto, JV; Moreira, Pedro; Silva, ML; Padrão, Patrícia

BackgroundThis study aims to analyze the effects of a potentially anti-inflammatory nutritional intervention in disease assessment parameters, inflammatory markers, and quality of life of fibromyalgia (FM) patients.MethodsA sample of 100 female patients diagnosed with FM, followed up at Portuguese Institute of Rheumatology (IPR) in Lisbon, is being randomly allocated in two groups. Patients in the intervention ...


Patient-reported quality of life and inflammatory biomarkers in Portuguese pati...

Silva, AR; Bernardo, A; Mesquita, MF; Patto, JV; Moreira, Pedro; Padrão, Patrícia; Silva, ML


Brain functional connectivity is altered in patients with Takotsubo Syndrome

Silva, AR; Magalhães, R; Arantes, C; Moreira, PS; Rodrigues, M; Marques, P; Marques, J; Sousa, N; Pereira, VH

Takotsubo syndrome (TTS) is an acute, reversible cardiomyopathy. The central autonomic nervous system (ANS) is believed to play a role in this disease. The aim of the present study was to investigate the patterns of brain functional connectivity in a sample of patients who had experienced a previous episode of TTS. Brain functional connectivity, both at rest and in response to the stressful stimulus of topical ...


Dietary interventions in Fibromyalgia: a systematic review

Silva, AR; Bernardo, A; Costa, J; Cardoso, A; Santos, P; Mesquita, MFd; Vaz Patto, J; Moreira, Pedro; Silva, ML; Padrão, Patrícia


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