7 documents found, page 1 of 1
Validity and reliability of the Cognitive Complaints in Bipolar Disorder Rating...
Lima,Flávia M.; Cardoso,Taiane A.; Serafim,Sílvia D.; Martins,Dayane S.; Solé,Brisa; Martínez-Arán,Anabel; Vieta,Eduard; Rosa,Adriane R.Abstract Introduction: In Brazil, there is no valid instrument to measure subjective cognitive dysfunction in bipolar disorder. The present study analyzed the psychometric properties of the Cognitive Complaints in Bipolar Disorder Rating Assessment (COBRA) in Brazilian bipolar patients. We further investigated the relationship between the COBRA, objective cognitive measures, and illness course variables. Method...
Cell therapy in the treatment of bipolar mania in an animal model: a proof of c...
Ascoli,Bruna M.; Colombo,Rafael; Géa,Luiza P.; Terraciano,Paula B.; Pizzato,Sabrina B.; de Oliveira,Fernanda S.; Cirne-Lima,Elizabeth; Kapczinski,FlávioAbstract Introduction The rationale of mesenchymal stem cells (MSCs) as a novel therapeutic approach in certain neurodegenerative diseases is based on their ability to promote neurogenesis. Hippocampal atrophy has been related to bipolar disorder (BD) in preclinical, imaging and postmortem studies. Therefore, the development of new strategies to stimulate the neurogenesis process in BD is crucial. Objectives To...
Cognitive performance and psychosocial functioning in patients with bipolar dis...
Vasconcelos-Moreno,Mirela P.; Bücker,Joana; Bürke,Kelen P.; Czepielewski,Leticia; Santos,Barbara T.; Fijtman,Adam; Passos,Ives C.; Kunz,MauricioObjective: To assess cognitive performance and psychosocial functioning in patients with bipolar disorder (BD), in unaffected siblings, and in healthy controls. Methods: Subjects were patients with BD (n=36), unaffected siblings (n=35), and healthy controls (n=44). Psychosocial functioning was accessed using the Functioning Assessment Short Test (FAST). A sub-group of patients with BD (n=21), unaffected sibling...
Challenges and developments in research of the early stages of bipolar disorder
Brietzke,Elisa; Rosa,Adriane R.; Pedrini,Mariana; Noto,Mariane N.; Kapczinski,Flavio; Scott,JanRecently, attention in the field of bipolar disorder (BD) has focused on prevention, including early detection and intervention, as these strategies have the potential to delay, lessen the severity, or even prevent full-blown episodes of BD. Although knowledge of the neurobiology of BD has advanced substantially in the last two decades, most research was conducted with chronic patients. The objective of this pa...
Shortened telomere length in bipolar disorder: a comparison of the early and la...
Barbé-Tuana,Florencia M.; Parisi,Mariana M.; Panizzutti,Bruna S.; Fries,Gabriel R.; Grun,Lucas K.; Guma,Fátima T.; Kapczinski,Flávio; Berk,MichaelObjective: Bipolar disorder (BD) has been associated with increased rates of age-related diseases, such as type II diabetes, metabolic syndrome, osteoporosis, and cardiovascular disorders. Several biological findings have been associated with age-related disorders, including increased oxidative stress, inflammation, and telomere shortening. The objective of this study was to compare telomere length among partic...
Pharmacological treatment and staging in bipolar disorder: evidence from clinic...
Goi,Pedro D.; Bücker,Joana; Vianna-Sulzbach,Mireia; Rosa,Adriane R.; Grande,Iria; Chendo,Ines; Sodré,Leonardo A.; Kauer-Sant'Anna,MarciaObjectives:Staging models for medical diseases are widely used to guide treatment and prognosis. Bipolar disorder (BD) is a chronic condition and it is among the most disabling disorders in medicine. The staging model proposed by Kapczinski in 2009 presents four progressive clinical stages of BD. Our aim was to evaluate pharmacological maintenance treatment across these stages in patients with BD.Methods:One hu...
Impairment in psychosocial functioning in patients with different subtypes of e...
Moser,Carolina Meira; Lobato,Maria Inês Rodrigues; Rosa,Adriane R.; Thomé,Emi; Ribar,Julia; Primo,Lucas; Santos,Ana Carolina Faedrich dosOBJECTIVE: To examine psychosocial functioning in eating disorder (ED) patients with restrictive and purgative subtypes. METHOD: Forty-four adult female patients with a diagnosis of ED were divided into restrictive (RP) and purgative (PP) groups according the presence of purgative symptoms. Functioning was assessed using the Functioning Assessment Short Test (FAST) and the Global Assessment of Functioning Scale...