65 documents found, page 1 of 7
pH-responsive hybrid nanoassemblies for cancer treatment: formulation developme...
Teixeira, Patrícia V.; Adega, Filomena; Martins-Lopes, Paula; Machado, Raul; Lopes, Carla Martins; Lúcio, MarleneCurrent needs for increased drug delivery carrier efficacy and specificity in cancer necessitate the adoption of intelligent materials that respond to environmental stimuli. Therefore, we developed and optimized pH-triggered drug delivery nanoassemblies that exhibit an increased release of doxorubicin (DOX) in acidic conditions typical of cancer tissues and endosomal vesicles (pH 5.5) while exhibiting significa...
Natural compounds: co-delivery strategies with chemotherapeutic agents or nucle...
Teixeira, Patrícia V.; Fernandes, Eduarda; Soares, Telma B.; Adega, Filomena; Lopes, Carla Martins; Lúcio, MarleneCancer is one of the leading causes of death, and latest predictions indicate that cancer- related deaths will increase over the next few decades. Despite significant advances in conventional therapies, treatments remain far from ideal due to limitations such as lack of selectivity, non-specific distribution, and multidrug resistance. Current research is focusing on the development of several strategies to impr...
Natural compounds: co-delivery strategies with chemotherapeutic agents or nucle...
Teixeira, Patrícia V.; Fernandes, Eduarda; Soares, Telma B.; Adega, Filomena; Lopes, Carla M.; Lúcio, M.Cancer is one of the leading causes of death, and latest predictions indicate that cancer- related deaths will increase over the next few decades. Despite significant advances in conventional therapies, treatments remain far from ideal due to limitations such as lack of selectivity, non-specific distribution, and multidrug resistance. Current research is focusing on the development of several strategies to impr...
pH-responsive hybrid nanoassemblies for cancer treatment: formulation developme...
Teixeira, Patrícia V.; Adega, Filomena; Martins-Lopes, Paula; Machado, Raul; Lopes, Carla M.; Lúcio, M.Current needs for increased drug delivery carrier efficacy and specificity in cancer necessitate the adoption of intelligent materials that respond to environmental stimuli. Therefore, we developed and optimized pH-triggered drug delivery nanoassemblies that exhibit an increased release of doxorubicin (DOX) in acidic conditions typical of cancer tissues and endosomal vesicles (pH 5.5) while exhibiting significa...
Gene expression association study in feline mammary carcinomas
Ferreira, Daniela; Martins, Bárbara; Soares, Maria; Correia, Jorge; Adega, Filomena; Ferreira, Fernando; Chaves, RaquelWorks on cancer-related genes expression using feline mammary carcinomas (FMCs) are scarce but crucial, not only to validate these tumours as models for human breast cancer studies but also to improve small animal practice. Here, the expression of the cancer-related genes TP53, CCND1, FUS, YBX1, PTBP1, c-MYC and PKM2 was evaluated by real-time RT-qPCR, in a population of FMCs clinically characterized and compar...
A comparison of the bioactivity and phytochemical profile of three different cu...
Liberal, Ângela; Calhelha, Ricardo C.; Pereira, Carla; Adega, Filomena; Barros, Lillian; Dueñas, Montserrat; Santos-Buelga, Celestino; Abreu, Rui M.V.The phytochemical profiles and bioactivities of red, white and pink globe amaranth (Gomphrena haageana K., Gomphrena globosa var. albiflora and Gomphrena sp., respectively), much less studied than the purple species (G. globosa L.), were compared. The chemical characterization of the samples included the analysis of macronutrients and individual profiles of sugars, organic acids, fatty acids, tocopherols, and p...
Antioxidant and anti-inflammatory properties of red, white and pink globe amara...
Liberal, Ângela; Pereira, Carla; Calhelha, Ricardo C.; Abreu, Rui M.V.; Adega, Filomena; Ferreira, Isabel C.F.R.Medicinal plants have been playing a vital role on human health and healing, representing one of the major sources of drugs in modem and traditional medicine [1]. Plants synthesize and preserve a variety of biochemical products that can be used as pharmaceutical compounds [2], and recently there has been an increasing interest in the therapeutic potential of plants as antioxidants and anti-inflammatories [3]. O...
Tocopherols as bioactive compounds in different cultivars of Gomphrena globosa L.
Liberal, Ângela; Pereira, Carla; Adega, Filomena; Barros, Lillian; Ferreira, Isabel C.F.R.Tocopherols are lipid-soluble molecules that belong to the group of the Vitamin E compounds, playing an essential role on human nutrition and health [1]. The term "Vitamin E" was first introduced as an important dietary factor for animal reproduction and, more than 40 years later, it was associated to antioxidant properties. Nowadays, most of the researches focus on the fundamental chemistry that explains their...
Defining the sister rat mammary tumor cell lines HH-16 cl.2/1 and HH-16.cl.4 as...
Louzada, Sandra; Chaves, Raquel; Adega, FilomenaCancer cell lines have been shown to be reliable tools in genetic studies of breast cancer, and the characterization of these lines indicates that they are good models for studying the biological mechanisms underlying this disease. Here, we describe the molecular cytogenetic/genetic characterization of two sister rat mammary tumor cell lines, HH-16 cl.2/1 and HH-16.cl.4, for the first time. Molecular cytogeneti...
New potential anti-hepatocellular carcinoma (HCC) agents: in vitro evaluation o...
Abreu, Rui M.V.; Queiroz, Maria João R.P.; Ferreira, Isabel C.F.R.; Calhelha, Ricardo C.; Adega, Filomena; Chaves, RaquelHepatocellular carcinoma (HCC) is a major health problem with more than 660,000 new cases per year worldwide [1]. HCC is resistant to commonly used treatments like chemotherapy and radiotherapy and new anti-HCC therapies are urgently needed. Sorafenib was the first approved small molecule against HCC and underlines the importance of identifying potential new anti-HCC drugs [2]. Thirty-two 6-substituted methyl 3...