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Health-related quality of life at 5 years of age for children born very preterm...

Kim, SW; Tian, X; Andronis, L; Maier, RF; Varendi, H; Seppänen, A-V; Siljehav, V; Draper, ES; Zeitlin, J; Petrou, S; Seppänen, AV; El Rafei, R

Background: This study aimed to investigate the health-related quality of life (HRQoL) at 5 years of age of European children born very preterm across multi-dimensional outcomes by presence and severity of congenital anomalies. Methods: The study used data from a European cohort of children born very preterm (<32 weeks of gestation) and followed up to 5 years of age (N = 3493). Multilevel Ordinary Least Squares...


Risk factors for cerebral palsy and movement difficulties in 5-year-old childre...

Aubert, AM; Costa, R; Johnson, S; Aden, U; Cuttini, M; Koopman-Esseboom, C; Lebeer, J; Varendi, H; Zemlin, M; Pierrat, V; Zeitlin, J

BackgroundMotor impairment is common after extremely preterm (EPT, <28 weeks' gestational age (GA)) birth, with cerebral palsy (CP) affecting about 10% of children and non-CP movement difficulties (MD) up to 50%. This study investigated the sociodemographic, perinatal and neonatal risk factors for CP and non-CP MD.MethodsData come from a European population-based cohort of children born EPT in 2011-2012 in 11 c...


Maternal education and cognitive development in 15 European very-preterm birth ...

Sentenac, M; Benhammou, V; Aden, U; Ancel, PY; Bakker, LA; Bakoy, H; Barros, H; Baumann, N; Bilsteen, JF; Boerch, K; Croci, I; Cuttini, M; Draper, E

Background Studies are sparse and inconclusive about the association between maternal education and cognitive development among children born very preterm (VPT). Although this association is well established in the general population, questions remain about its magnitude among children born VPT whose risks of medical and developmental complications are high. We investigated the association of maternal education...


Cohort Profile: Effective Perinatal Intensive Care in Europe (EPICE) very prete...

Zeitlin, J; Maier, RF; Cuttini, M; Aden, U; Boerch, K; Gadzinowski, J; Jarreau, PH; Lebeer, J; Norman, M; Pedersen, P; Petrou, S; Pfeil, JM; Toome, L

The EPICE cohort is a geographically defined study of still-births and live births from 22 þ 0 to 31 þ 6 weeks of gestation in 19 European regions (Fig. 1). Regions were selected with respect to geographic and organizational diversity and feasibility, meaning they had systems for collecting population data on VPT babies that could be modified to integrate the study protocol. In France, the EPICE study includes ...


Maternal education and language development at 2 years corrected age in childre...

Sentenac, M; Johnson, S; Charkaluk, ML; Sëppanen, AV; Aden, U; Cuttini, M; Maier, R; Mannamaa, M; Zeitlin, J; EPICE group

Background Socioeconomic factors influence language development in the general population, but the association remains poorly documented in children born very preterm (VPT). We assessed the impact of maternal education on language development in children born VPT and effect modification by perinatal risk. Methods Data were from the Effective Perinatal Intensive Care in Europe (EPICE) population-based cohort of ...


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