6 documents found, page 1 of 1
Global age-sex-specific mortality, life expectancy, and population estimates in...
Schumacher, AE; Kyu, HH; Aali, A; Abbafati, C; Abbas, J; Abbasgholizadeh, R; Abbasi, MA; Abbasian, M; Abd ElHafeez, S; Abdelmasseh, M; Abd Elsalam, SBackground: Estimates of demographic metrics are crucial to assess levels and trends of population health outcomes. The profound impact of the COVID-19 pandemic on populations worldwide has underscored the need for timely estimates to understand this unprecedented event within the context of long-term population health trends. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 provides n...
Paclitaxel: Application in Modern Oncology and Nanomedicine-Based Cancer Therapy
Sharifi-Rad, J; Quispe, C; Patra, JK; Singh, YD; Panda, MK; Das, G; Adetunji, CO; Michael, OS; Sytar, O; Polito, L; Živkovic, J; Martins, NPaclitaxel is a broad-spectrum anticancer compound, which was derived mainly from a medicinal plant, in particular, from the bark of the yew tree Taxus brevifolia Nutt. It is a representative of a class of diterpene taxanes, which are nowadays used as the most common chemotherapeutic agent against many forms of cancer. It possesses scientifically proven anticancer activity against, e.g., ovarian, lung, and brea...
Mushrooms-Rich Preparations on Wound Healing: From Nutritional to Medicinal Att...
Sharifi-Rad, J; Butnariu, M; Ezzat, SM; Adetunji, CO; Imran, M; Sobhani, SR; Tufail, T; Hosseinabadi, T; Ramírez-Alarcón, K; Martorell, M; Maroyi, AMushrooms have a significant role in human diet as functional food and as a nutraceutical resource. The combination of its umami flavor, protein, vitamins, minerals and carbohydrates has meant that mushrooms could be considered a cheap food source for a long time in many countries. Moreover, mushrooms contain an excellent variety of bioactive metabolites that can be successful in both prevention and treatment o...
Apium plants: Beyond simple food and phytopharmacological applications
Salehi, B; Venditti, A; Frezza, C; Yücetepe, A; Altuntas, Ü; Uluata, S; Butnariu, M; Sarac, I; Shaheen, S; Petropoulos, SA; Matthews, KR; Kiliç, CSApium plants belong to the Apiaceae family and are included among plants that have been in use in traditional medicine for thousands of years worldwide, including in the Mediterranean, as well as the tropical and subtropical regions of Asia and Africa. Some highlighted medical benefits include prevention of coronary and vascular diseases. Their phytochemical constituents consist of bergapten, flavonoids, glycos...
Phytochemicals in prostate cancer: From bioactive molecules to upcoming therape...
Salehi, B; Fokou, PVT; Yamthe, LRT; Tali, BT; Adetunji, CO; Rahavian, A; Mudau, FN; Martorell, M; Setzer, WN; Rodrigues, CF; Martins, N; Cho, WCProstate cancer is a heterogeneous disease, the second deadliest malignancy in men and the most commonly diagnosed cancer among men. Traditional plants have been applied to handle various diseases and to develop new drugs. Medicinal plants are potential sources of natural bioactive compounds that include alkaloids, phenolic compounds, terpenes, and steroids. Many of these naturally-occurring bioactive constitue...
Natural products and synthetic analogs as a source of antitumor drugs
Sharifi-Rad, J; Ozleyen, A; Tumer, TB; Adetunji, CO; Omari, NE; Balahbib, A; Taheri, Y; Bouyahya, A; Martorell, M; Martins, N; Cho, WCCancer is a heterogeneous disease and one of the major issues of health concern, especially for the public health system globally. Nature is a source of anticancer drugs with abundant pool of diverse chemicals and pharmacologically active compounds. In recent decade, some natural products and synthetic analogs have been investigated for the cancer treatment. This article presents the utilization of natural prod...