4 documents found, page 1 of 1
Fbxo42 promotes the degradation of Ataxin-2 granules to trigger terminal Xbp1 s...
Santos, Cristiana C.; Schweizer, Nadine; Cairrão, Fátima; Ramirez, Juanma; Osinalde, Nerea; Yang, Ming; Gaspar, Catarina J.; Rasheva, Vanya I.Funding Information: We would like to thank Hyung Don Ryoo, Andreas Bergmann, Iswar Hariharan, Patrick Emery, the Bloomington Drosophila Stock Center, FlyORF and the Developmental Studies Hybridoma Bank (DSHB) for fly stocks, plasmids and antibodies. We would like to thank Hyung Don Ryoo, Avi Ashkenazi and Brenda Schulman for comments on the manuscript. We thank Julia Domingos (Insta: cenasdajul) for the art wo...
The ADAM17 sheddase complex regulator iTAP/Frmd8 modulates inflammation and tum...
Badenes, Marina; Burbridge, Emma; Oikonomidi, Ioanna; Amin, Abdulbasit; de Carvalho, Érika; Kosack, Lindsay; Mariano, Camila; Domingos, PedroFunding Information: The authors thank the Animal Facility, the Histopathology, the Advanced Imaging, and Flow cytometry units and the antibody service of the Instituto Gulbenkian de Ciência. We thank Cristina Branco for reagents and Sarah Maguire for advice about expression correlation analysis. We thank Colin Crump (Cambridge, UK) for providing the HSV-1 DNA. We thank Stefan Rose-John and Cristina Branco for ...
Xport-A functions as a chaperone by stabilizing the first five transmembrane do...
Gaspar, Catarina J.; Gomes, Tiago; Martins, Joana C.; Melo, Manuel N.; Adrain, Colin; Cordeiro, Tiago N.; Domingos, Pedro M.Funding Information: The authors acknowledge Fundação para a Ciência e a Tecnologia, I.P. (FCT) for funding project MOSTMICRO-ITQB , with references UIDB/04612/2020 and UIDP/04612/2020 . M.N.M. further acknowledges FCT for fellowship CEECIND/04124/2017 and T.N.C. is the recipient of the grant CEECIND/01443/2017 . The project leading to these results was funded by the grants LCF/PR/HR17/52150018 ( 'la Caixa' Fou...
Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metal...
Cavadas, Miguel; Oikonomidi, Ioanna; Gaspar, Catarina J.; Burbridge, Emma; Badenes, Marina; Félix, Inês; Bolado, Alfonso; Hu, Tianyi; Bileck, AndreaCell surface metalloproteases coordinate signaling during development, tissue homeostasis, and disease. TACE (TNF-α-converting enzyme), is responsible for cleavage (“shedding”) of membrane-tethered signaling molecules, including the cytokine TNF, and activating ligands of the EGFR. The trafficking of TACE within the secretory pathway requires its binding to iRhom2, which mediates the exit of TACE from the endop...