3 documents found, page 1 of 1
Contacts in death: The role of the ER-mitochondria axis in acetic acid-induced ...
Martins, Vítor M.; Fernandes, Tânia R.; Afonso, Catarina B.; Lopes, Diana; Domingues, Maria R. M.; Côrte-Real, Manuela; Sousa, Maria JoãoEndoplasmic reticulum-mitochondria contact sites have been a subject of increasing scientific interest since the discovery that these structures are disrupted in several pathologies. Due to the emerging data that correlate endoplasmic reticulum-mitochondria contact sites function with known events of the apoptotic program, we aimed to dissect this interplay using our well-established model of acetic acid-induce...
Evaluation of air oxidized PAPC: a multi laboratory study by LC-MS/MS
Ni, Zhixu; Sousa, Bebiana C.; Colombo, Simone; Afonso, Catarina B.; Melo, Tania; Pitt, Andrew R.; Spickett, Corinne M.; Domingues, PedroOxidized LDL (oxLDL) has been shown to play a crucial role in the onset and development of cardiovascular disorders. The study of oxLDL, as an initiator of inflammatory cascades, led to the discovery of a variety of oxidized phospholipids (oxPLs) responsible for pro-inflammatory actions. Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (PAPC) is frequently used by the scientific community as a re...
European contribution to the study of ROS: A summary of the findings and prospe...
Egea, Javier; Fabregat, Isabel; Frapart, Yves M; Ghezzi, Pietro; Görlach, Agnes; Kietzmann, Thomas; Kubaichuk, Kateryna; Knaus, Ulla G.The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregu...