4 documents found, page 1 of 1
Multiple Myeloma Treatment Guidelines by the Portuguese Group of Multiple Myeloma
João, Cristina; Bergantim, Rui; Santos, Joana; Afonso, Celina; Bernardo, Paulo; Coelho, Henrique; Costa, Carlos; Esteves, Graça; Freitas, José GuilhermeThe treatment of multiple myeloma has profoundly changed with the introduction of several innovative therapies. The optimization of therapeutic sequencing through the combined use of the various drugs developed in recent years and the attention given to the characteristics of patients have allowed the reduction of toxicities and increased survival and quality of life of patients with multiple myeloma. These tre...
Iron Metabolism, Biomarkers, Iron Overload and Chelation: Consensus in Myelodys...
Brilhante, Dialina; Aldeia, Carlos; de Fátima Ferreira, Maria; Afonso, Celina; Rodrigues, Susana; Ferreira, Jorge; Rey, Carmen; Sousa-Mendes, DianaMyelodysplastic syndromes (MDS) are a diverse group ofmyeloid neoplasias, characterized by cytopenias stemmingfrom ineffective hematopoiesis and by an increased risk ofprogression to acute myeloid leukemia. They affect 5/100000 people per year in Portugal, among which more than60% will become transfusion-dependent during the courseof the disease. Cytopenias may lead to significant morbidityand their correct man...
The role of TMPRSS6 gene variants in different types of iron deficiency anaemia...
Gonçalves, Lúcia; Nobre Jesus, Gustavo; Afonso, Celina; Vieira, Albertina; Maia, Raquel; Correia, Leonor; Faustino, PaulaObjective: Iron-refractory iron-deficiency anaemia (IRIDA) is a rare autosomal-recessive disease characterized by severe hypochromic microcytic anemia, low serum iron and transferrin saturation, normal-high ferritin and inappropriate high levels of the hormone hepcidin. Patients are unresponsive to iron oral treatment and present a slow persistent response to intravenous iron injections. The disease is caused b...
Implementation of the pull levelling project in a car radio assembly firm
Afonso, Celina; Alves, Anabela CarvalhoThis paper presents some results from the implementation of pull levelling strategy between the final assembly lines and the Original Equipment Manufacturing (OEM) clients of a car radio assembly firm. In order to respond quickly to the clients the firm maintained a stock level of, approximately, ten days of finished product for each client. This implies high costs for the firm. The implementation of the pull l...