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Complete blood count parameters as biomarkers of retinopathy of prematurity: a ...
Fevereiro-Martins, Mariza; Santos, Ana Carolina; Marques-Neves, Carlos; Guimarães, Hercília; Bicho, Manuel; Afonso, Conceição; Ferreira, JoanaPurpose: To evaluate complete blood count (CBC) parameters in the first week of life as predictive biomarkers for the development of retinopathy of prematurity (ROP). Methods: Multicenter, prospective, observational study of a cohort of preterm infants born with gestational age (GA) < 32 weeks or birth weight < 1500 g in eight Portuguese neonatal intensive care units. All demographic, clinical, and laboratory d...
Sickle cell anemia - nitric oxide related genetic modifiers of hematological an...
Aguiar, Laura; Matos, Andreia; Gil, Ângela; Afonso, Conceição; Braga, Lígia; Lavinha, João; Kjollerstrom, Paula; Faustino, Paula; Bicho, ManuelBACKGROUND: Sickle cell anemia (SCA) is an inherited blood disorder. SCA patients present clinical and hematologic variability that cannot be only explained by the single mutation in the beta-globin gene. Others genetic modifiers and environmental effects are important for the clinical phenotype. SCA patients present arginine deficiency that contributes to a lower nitric oxide (NO) bioactivity. OBJECTIVE: The a...
Sickle cell anemia - nitric oxide related genetic modifiers of hematological an...
Aguiar, Laura; Matos, Andreia; Gil, Ângela; Afonso, Conceição; Braga, Lígia; Lavinha, João; Kjollerstrom, Paula; Faustino, Paula; Bicho, ManuelSickle cell anemia (SCA) is an inherited blood disorder with a broad range of complications, including vaso-occlusion and hemolytic anemia. SCA patients present arginine deficiency that contributes to a lower nitric oxide (NO) bioactivity. The amino acid citrulline increases arginine levels and promotes NO production. We studied the association between hematological and biochemical parameters with genetic varia...
Genetic variants in endothelial nitric oxide synthase gene are modifiers of the...
Aguiar, Laura; Matos, Andreia; Gil, Ângela; Afonso, Conceição; Braga, Lígia; Lavinha, João; Kjollerstrom, Paula; Faustino, Paula; Bicho, ManuelSickle Cell Anemia (SCA) is an autosomal recessive hereditary anemia characterized by the presence of hemoglobin S (Hb S). This disease is caused by a single mutation in beta-globin gene with a corresponding amino acid substitution at the sixth position of the beta-globin chain. The easily ability of Hb S to polymerize in deoxygenated conditions gives rise to abnormal sickled red blood cells. Vaso-occlusion and...
Educação Ambiental e Resíduos – um recurso para (Re) utilizar com criatividade
Pinto, Adelina; Afonso, Conceição; Lopes, RaquelApresentação O trabalho desenvolvido, inserido no Seminário Internacional “Educação, Ambiente, Turismo e Desenvolvimento Comunitário em São Tomé e Príncipe” no âmbito das “Oficinas de Reciclagem e Reutilização Criativa e Desenvolvimento Comunitário” e “Resíduos: um recurso para (Re)utilizar com criatividade”, realizadas nas Roças de S. João e Diogo Vaz, respectivamente, apresenta um contributo de uma experiênci...