21 documents found, page 1 of 3
Bidirectional interactions between the menstrual cycle, exercise training, and ...
Rocha-Rodrigues, S; Sousa, M; Reis, PL; Leão, C; Cardoso-Marinho, B; Massada, M; Afonso, JWomen have a number of specificities that differentiate them from men. In particular, the role of sex steroid hormones and the menstrual cycle (MC) significantly impact women’s physiology. The literature has shown nonlinear relationships between MC, exercise, and nutritional intake. Notably, these relationships are bidirectional and less straightforward than one would suppose. For example, the theoretical impli...
Impact of physical activity on redox status and nitric oxide bioavailability in...
Leite-Almeida, L; Morato, M; Cosme, D; Afonso, J; Areias, JC; Guerra, A; Caldas, Afonso, A; Albino-Teixeira, A; Sousa, T; Correia-Costa, LNutritional status might contribute to variations induced by physical activity (PA) in redox status biomarkers. We investigated the influence of PA on redox status and nitric oxide (NO) production/metabolism biomarkers in nonoverweight and overweight/obese prepubertal children. We performed a cross-sectional evaluation of 313 children aged 8-9 years (163 nonoverweight, 150 overweight/obese) followed since birth...
Strength training to prevent falls in older adults: A systematic review with me...
Claudino, JG; Afonso, J; Sarvestan, J; Lanza, MB; Pennone, J; Filho, CAC; Serrão, JC; Espregueira-Mendes, J; Vasconcelos, ALV; Andrade, MPWe performed a systematic review with meta-analysis of randomized controlled trials (RCTs) to assess the effects of strength training (ST), as compared to alternative multimodal or unimodal exercise programs, on the number of falls in older adults (=60 years). Ten databases were consulted (CINAHL, Cochrane Library, EBSCO, EMBASE, PEDro, PubMed, Scielo, Scopus, SPORTDiscus and Web of Science), without limitation...
Skeletal muscle–adipose tissue–tumor axis: Molecular mechanisms linking exercis...
Rocha-Rodrigues, S; Matos, M; Afonso, J; Mendes-Ferreira, M; Abade, E; Teixeira, E; Silva, B; Murawska-Cialowicz, E; Oliveira, MJ; Ribeiro, RIncreased visceral adiposity may influence the development of prostate cancer (PCa) aggressive tumors and cancer mortality. White adipose tissue (WAT), usually referred to as periprostatic adipose tissue (PPAT), surrounds the prostatic gland and has emerged as a potential mediator of the tumor microenvironment. Exercise training (ET) induces several adaptations in both skeletal muscle and WAT. Some of these eff...
Fecal Dipeptidyl Peptidase-4: An Emergent Biomarker in Inflammatory Bowel Disease
Pinto-Lopes, P; Melo, F; Afonso, J; Pinto-Lopes, R; Rocha, C; Melo, D; Macedo, G; Dias, CC; Carneiro, F; Magro, FINTRODUCTION: Dipeptidyl peptidase-4 (DPP-4) is a membrane-bound glycoprotein that acts as a receptor but also exists in a soluble form. It has been recognized as a mediator of inflammation and considered a biomarker in inflammatory bowel disease (IBD). METHODS: We evaluated a prospectively recruited cohort, consisting of 101 patients with IBD, using validated clinical indexes; 22 patients with ulcerative colit...
The Hamstrings: Anatomic and Physiologic Variations and Their Potential Relatio...
Afonso, J; Rocha-Rodrigues, S; Clemente, FM; Aquino, M; Nikolaidis, PT; Sarmento, H; Fílter, A; Olivares-Jabalera, J; Ramirez-Campillo, RThe incidence and recurrence of hamstrings injuries are very high in sports, posing elevated performance and financial-related costs. Attempts to identify the risk factors involved in predicting vulnerability to hamstrings injury is important for designing exercise-based programs that aim to mitigate the rate and severity of hamstrings injuries and improve rehabilitation strategies. However, research has shown ...
Low Golimumab Trough Levels at Week 6 Are Associated With Poor Clinical, Endosc...
Magro, F; Lopes, S; Silva, M; Coelho, R; Portela, F; Branquinho, D; Correia, L; Fernandes, S; Cravo, M; Caldeira, P; Sousa, H T; Patita, M; Lago, PBackground and aims: Golimumab has an established exposure-response relationship in patients with ulcerative colitis [UC]. However, the association of serum golimumab trough levels [TL] with objective markers of disease activity, such as endoscopic and histological activity scores and concentrations of biomarkers, remains less understood. This report describes the relationship of serum golimumab TL at the end o...
Accuracy of the new rapid test for monitoring adalimumab levels
Rocha, C; Afonso, J; Lago, P; Arroja, B; Vieira, AI; Dias, CC; Magro, FThe loss of response to adalimumab (ADL) has been related to low serum concentrations at trough. Currently, most methods commercially available for the quantification of ADL are enzyme-linked immunosorbent assay (ELISA) based, with a turnaround time of approximately 8 h, delaying the target dosage adjustment to the subsequent infusion. In this study, we aimed to evaluate the performance of the newly available r...
Soluble Human Suppression of Tumorigenicity 2 Is Associated with Endoscopic Act...
Magro, F; Lopes, S; Silva, M; Coelho, R; Portela, F; Branquinho, D; Correia, L; Fernandes, S; Cravo, M; Caldeira, P; Tavares de Sousa, H; Patita, MBackground: Suppressor of Tumorigenicity 2 (ST2) is an IL33 receptor detected in the mucosa and serum of ulcerative colitis (UC) patients. We evaluated soluble ST2 (sST2) as a surrogate biomarker of disease outcome and therapeutic response, in moderate-to-severe UC patients treated with golimumab. Methods: We conducted an open-label single-arm multicentre prospective study. At screening/baseline, week 6 (W6) an...
Accuracy of Faecal Calprotectin and Neutrophil Gelatinase B-associated Lipocali...
Magro, F; Lopes, S; Coelho, R; Cotter, J; Castro, F; Sousa, H; Salgado, M; Andrade, P; Vieira, A; Figueiredo, P; Caldeira, P; Sousa, A; Duarte, MBACKGROUND AND AIMS: Mucosal healing and histological remission are different targets for patients with ulcerative colitis, but both rely on an invasive endoscopic procedure. This study aimed to assess faecal calprotectin and neutrophil gelatinase B-associated lipocalin as biomarkers for disease activity in asymptomatic ulcerative colitis patients. METHODS: This was a multicentric cross-sectional study includin...