12 documents found, page 1 of 2
Serum neutrophil biomarkers to predict crohn's disease progression and inflixim...
Magalhaes, D.; Santiago, M.; Patita, M.; Arroja, B.; Lago, P.; Rosa, I.; Sousa, Helena Tavares; Ministro, P.; Mocanu, I.; Vieira, A.; Castela, J.Background and aims: Predicting the treatment outcomes of biological therapies is an unmet need in Crohn's Disease. In this study, we explored the potential of serum neutrophil-related biomarkers to predict infliximab therapeutic results and disease progression in Crohn's Disease patients, over a 2-year period, in a real-world setting. Methods: The study included 100 asymptomatic Crohn's Disease patients in the...
Emergence of the Asian lineage of Zika virus in Angola: an outbreak investigation
Hill, S.C.; Vasconcelos, J.; Neto, Z.; Jandondo, D.; Zé-Zé, L.; Aguiar, R.S.; Xavier, J.; Thézé, J.; Mirandela, M.; Micolo Cândido, A.L.; Vaz, F.Background: Zika virus infections and suspected microcephaly cases have been reported in Angola since late 2016, but no data are available about the origins, epidemiology, and diversity of the virus. We aimed to investigate the emergence and circulation of Zika virus in Angola. Methods: Diagnostic samples collected by the Angolan Ministry of Health as part of routine arboviral surveillance were tested by real-t...
Low Golimumab trough levels at week 6 are associated with poor clinical, endosc...
Magro, F.; Lopes, S.; Silva, M.; Coelho, R.; Portela, F.; Branquinho, D.; Correia, L.; Fernandes, S.; Cravo, M.; Caldeira, Paulo; Sousa, Helena TavaresBackground and Aims: Golimumab has an established exposure-response relationship in patients with ulcerative colitis [UC]. However, the association of serum golimumab trough levels [TL] with objective markers of disease activity, such as endoscopic and histological activity scores and concentrations of biomarkers, remains less understood. This report describes the relationship of serum golimumab TL at the end o...
Utilização de sistemas de aquecimento por ar e por água quente em estufas local...
Afonso, J.; Baptista, F.; Fitas da Cruz, V.; Garcia, J.L.Um dos principais objectivos da produção em estufa é a obtenção de plantas, em quantidade e qualidade, que de outro modo não seria possível devido às condições adversas do meio exterior. No entanto, de modo a obter no interior da estufa as condições de temperatura e humidade adequadas é normalmente necessário recorrer a técnicas de condicionamento ambiental, como sejam, a ventilação e o aquecimento. Neste traba...
The performance of Remicade (R)-optimized quantification assays in the assessme...
Magro, F.; Rocha, C.; Vieira, A. I.; Sousa, H. T.; Rosa, I; Lopes, S.; Carvalho, J.; Dias, C. C.; Afonso, J.Background: The advent of Remicade (R) biosimilars, Remsima (R), Inflectra (R) and, more recently, Flixabi (R), has brought along the potential to decrease the costs associated with this therapy, therefore increasing its access to a larger group of patients. However, and in order to assure a soft transition, one must make sure the assays and algorithms previously developed and optimized for Remicade perform equ...
The need for technological updating in radiology: a case study in CT
Afonso, J.; Borlinhas, Filipa; Venâncio, JoséIntroduction - The exposure of the population to ionizing radiation following radiologic exams has become a topic of special concern due to its growing importance. Computed Tomography (CT) technology is well-known to be the main accountable for the significant increase verified. In this context and derived from the concerns of health personnel, as well as media highlight on this topic, manufacturers have been d...
Soluções de pavimentos rodoviários para países com climas tropicais – projeto d...
Antunes, V.; Fonseca, P.; Afonso, J.; Gomes, L.; Antunes, M. L.; Freire, A. C.; Pereira, Paulo A. A.; Silva, Hugo Manuel Ribeiro Dias da; Santos, L. P.Algumas empresas do setor da construção que integram a Plataforma Tecnológica Portuguesa da Construção (PTPC) decidiram promover a cooperação tecnológica entre si e com as entidades do Sistema Científico e Tecnológico Nacional (SCTN) para o desenvolvimento de novas soluções de pavimentação rodoviária para aplicação em países de clima tropical, nomeadamente ao nível das misturas betuminosas e das camadas de solo...
Avaliação de estruturas de pavimentos rodoviários através de pista e simulador ...
Antunes, V.; Fonseca, P.; Afonso, J.; Gomes, L.; Picado Santos, L.; Freire, A. C.; Neves, J.; Silva, Hugo Manuel Ribeiro Dias da; Antunes, M. L.Os ensaios acelerados de pavimentos rodoviários consistem na aplicação controlada de um carregamento vertical, através de uma roda normalizada que circula a uma velocidade controlada, simulando as cargas reais introduzidas pelo tráfego pesado. Em condições de temperatura e humidade controladas, os ensaios acelerados permitem simular num período de tempo reduzido as ações a que um pavimento está sujeito ao longo...
Proactive therapeutic drug monitoring of infliximab: a comparative study of a n...
Afonso, J.; Lopes, S.; Gonçalves, R.; Caldeira, Paulo; Lago, P.; Sousa, Helena Tavares; Ramos, J.; Gonçalves, A. R.; Ministro, P.; Rosa, I.BackgroundTherapeutic drug monitoring is a powerful strategy known to improve the clinical outcomes and to optimise the healthcare resources in the treatment of autoimmune diseases. Currently, most of the methods commercially available for the quantification of infliximab (IFX) are ELISA-based, with a turnaround time of approximately 8h, and delaying the target dosage adjustment to the following infusion.AimTo ...
Fetal-maternal interface impedance parallels local NADPH oxidase related supero...
Guedes-Martins, L.; Silva, E.; Gaio, R.; Saraiva, J.; Soares, A.; Afonso, J.; Macedo, F.; Almeida, H.Blood flow assessment employing Doppler techniques is a useful procedure in pregnancy evaluation, as it may predict pregnancy disorders coursing with increased uterine vascular impedance, as pre-eclampsia. While the local causes are unknown, emphasis has been put on reactive oxygen species (ROS) excessive production. As NADPH oxidase (NOX) is a ROS generator, it is hypothesized that combining Doppler assessment...