39 documents found, page 1 of 4
A ascensão de genes de resistência a antibióticos em Staphylococcus aureus: rev...
Reguinga , Patrícia; Afonso, Joana; Carmo, Matilde; Ribeiro, Edna; EdnaIntrodução – O Staphylococcus aureus resistente à meticilina (MRSA) tem-se disseminado globalmente, tornando-se endémico em muitos hospitais e comunidades. Além da meticilina, diversas estirpes de S. aureus têm mostrado resistência a uma variedade de outros antibióticos. Esta resistência é conferida por genes cuja presença e expressão são facilitadas por uma alta taxa de recombinação genética e pela capacidade ...
Enterprise Europe Network (EEN) : Notas para a preparação de relatórios de sust...
Miranda, Miguel; Catarino, Justina; Couto, António; Lopes, Fernando; Afonso, JoanaRESUMO: A Enterprise Europe Network (EEN) é uma rede de serviços que tem como objetivo ajudar as empresas ou organizações a inovar e a competir no quadro internacional. As entidades que pretendam inovar, competir e estabelecer parcerias com as suas congéneres estrangeiras ou que necessitam também de instrumentos que lhes permitam avaliar o desempenho do seu modelo de negócio podem fazê-lo através desta rede. Da...
Thiopurines have no impact on outcomes of Crohn's disease patients beyond 12 mo...
Sousa, Paula; Patita, Marta; Arroja, Bruno; Lago, Paula; Rosa, Isadora; Sousa, Helena Tavares; Ministro, Paula; Mocanu, Irina; Vieira, AnaThe emergence of new treatments the inflammatory bowel diseases (IBD) raised questions regarding the role of older agents, namely thiopurines. Aims: To clarify the benefits of combination treatment with thiopurines on Crohn's disease (CD) patients in the maintenance phase of infliximab. Methods: In this analysis of the 2 -year prospective multicentric DIRECT study, patients were assessed in terms of clinical ac...
How many biomarker measurements are needed to predict prognosis in Crohn's dise...
Magro, Fernando; Estevinho, Maria Manuela; Catalano, Gaia; Patita, Marta; Arroja, Bruno; Lago, Paula; Rosa, Isadora; Sousa, Helena TavaresBackgroundTimely stratification of Crohn's disease (CD) is essential for patients' management. The use of noninvasive accurate biomarkers is key to monitor treatment and to pursue mucosal healing, the ultimate treatment endpoint in CD. ObjectiveWe aimed to evaluate the performance of readily available biomarkers and develop risk matrices to predict CD progression. MethodsData from 289 CD patients receiving infl...
Urinary tract infection in primary care: state of the art
Machado, Gabriela; Marinho, Ana; Afonso, Joana; Freitas, Marta; Silva, Mara; Coelho, RicardoIntroduction: Urinary tract infection (UTI) is the second most prevalent infection in the community. Aims: To determine the microorganisms responsible for UTI in Primary Health Care and their profile of sensitivity to antibiotics, as well as to evaluate if the approach of the UTI is concordant with the National Health Authority’s recommendations. Methods: Observational and retrospective study in four primary he...
Serum dipeptidyl peptidase 4 : a predictor of disease activity and prognosis in...
Pinto Lopes, Pedro; Afonso, Joana; Pinto Lopes, Rui; Rocha, Cátia; Lago, Paula; Gonçalves, Raquel; Tavares de Sousa, Helena; Macedo, GuilhermeBackground: Serum dipeptidyl peptidase 4 (DPP-4) has drawn particular interest as a biomarker in inflammatory bowel disease (IBD), as this protease inactivates several peptides that participate in the inflammatory cascade. Methods: Two prospectively recruited cohorts consisting of 195 patients (101 had Crohn’s disease [CD] and 94 had ulcerative colitis [UC]) were evaluated using clinical indexes and followed up...
Comparing the continuous geboes score with the Robarts Histopathology Index: de...
Magro, Fernando; Lopes, Joanne; Borralho, Paula; Lopes, Susana; Coelho, Rosa; Cotter, Jose; de Castro, Francisca Dias; Sousa, Helena TavaresBackground and Aims: The histological status of ulcerative colitis [UC] patients in clinical and endoscopic remission has gained space as an important prognostic marker and a key component of disease monitoring. Our main aims were to compare two histological indexes-the continuous Geboes score [GS] and the Robarts Histopathology index [RHI]-regarding their definitions of histological remission and response, and...
Serum dipeptidyl peptidase 4: a predictor of disease activity and prognosis in ...
Pinto-Lopes, Pedro; Afonso, Joana; Pinto-Lopes, Rui; Rocha, Catia; Lago, Paula; Goncalves, Raquel; Sousa, Helena Tavares; Macedo, GuilhermeBackground: Serum dipeptidyl peptidase 4 (DPP-4) has drawn particular interest as a biomarker in inflammatory bowel disease (IBD), as this protease inactivates several peptides that participate in the inflammatory cascade. Methods: Two prospectively recruited cohorts consisting of 195 patients (101 had Crohn’s disease [CD] and 94 had ulcerative colitis [UC]) were evaluated using clinical indexes and followed up...
Accuracy of the new rapid test for monitoring adalimumab levels
Rocha, Cátia; Afonso, Joana; Lago, Paula; Arroja, Bruno; Vieira, Ana I.; Dias, Cláudia C.; Magro, FernandoBackground: The loss of response to adalimumab (ADL) has been related to low serum concentrations at trough. Currently, most methods commercially available for the quantification of ADL are enzyme-linked immunosorbent assay (ELISA) based, with a turnaround time of approximately 8 h, delaying the target dosage adjustment to the subsequent infusion. In this study, we aimed to evaluate the performance of the newly...
Soluble human Suppression of Tumorigenicity 2 is associated with endoscopic act...
Magro, Fernando; Lopes, Susana; Silva, Marco; Coelho, Rosa; Portela, Francisco; Branquinho, Diogo; Correia, Luís; Fernandes, Samuel; Cravo, MaríliaSuppressor of Tumorigenicity 2 (ST2) is an IL33 receptor detected in the mucosa and serum of ulcerative colitis (UC) patients. We evaluated soluble ST2 (sST2) as a surrogate biomarker of disease outcome and therapeutic response, in moderate-to-severe UC patients treated with golimumab.