10 documents found, page 1 of 1
Glucose metabolism reprogramming in bladder cancer: hexokinase 2 (HK2) as progn...
Afonso, Julieta; Gonçalves, Céline; Costa, Marta; Ferreira, Débora Carina Gonçalves Abreu; Santos, Lúcio; Longatto-Filho, Adhemar; Baltazar, FátimaProliferating cancer cells are able to reprogram their energy metabolism, favouring glycolysis even in the presence of oxygen and fully functioning mitochondria. Research is needed to validate the glycolysis-related proteins as prognostic/predictive biomarkers in urothelial bladder carcinoma (UBC), a malignancy tagged by high recurrence rates and poor response to chemotherapy. Here, we assessed GLUT1, HK2, PFKL...
Exosome-mediated MEK1 silencing is a promising approach against triple negative...
Ferreira, Débora; Cátia S. Pereira; Costa, Marta; Afonso, Julieta; Longatto, Adhemar; Baltazar, Fátima; Kalluri, Raghu; Moreira, João N.[Excerpt] Introduction: Breast cancer is a major public health problem worldwide being the most diagnosed cancer in women [1] . Triple negative breast cancer (TNBC) represents 10-20% of all breast cancers and is characterized by the absence of hormone receptors (progesterone and estrogen) and lack of expression of epidermal growth factor receptor 2. Furthermore, it is also described to have poor prognosis due t...
Lymphangiogenic VEGF-C and VEGFR-3 expression in genetically characterised gast...
Torres de Oliveira, Antonio Talvane; Reis, Rui M.; Afonso, Julieta; Martinho, Olga; Matos, Delcio; Carvalho, Andre Lopes; Vazquez, Vinicius LimaMade available in DSpace on 2020-12-10T16:35:48Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-12-01; Portuguese Science and Technology Foundation; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); This study aimed to assess the distribution of VEGF-C and VEGFR-3 expression in gastrointestinal stromal tumours (GISTs), and to analyse the value of lymphatic vessel density (LVD) in a tu...
Clinical significance of metabolism-related biomarkers in non-Hodgkin lymphoma-...
Afonso, Julieta; Pinto, Tatiana; Simoes-Sousa, Susana; Schmitt, Fernando; Longatto-Filho, Adhemar [UNESP]; Pinheiro, Celine; Marques, HerlanderMade available in DSpace on 2019-10-04T12:14:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-06-01; Northern Portugal Regional Operational Programme (NORTE 2020) through the European Regional Development Fund (FEDER); Northern Portugal Regional Operational Programme (NORTE 2020) through Competitiveness Factors Operational Programme (COMPETE); Foundation for Science and Technology (FCT); FCT; PurposeIn...
Metabolic coupling in urothelial bladder cancer compartments and its correlatio...
Afonso, Julieta; Santos, Lucio L.; Morais, Antonio; Amaro, Teresina; Longatto-Filho, Adhemar [UNESP]; Baltazar, FatimaMade available in DSpace on 2018-11-26T15:28:45Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-02-01; Life and Health Sciences Research Institute (ICVS) from the School of Health Sciences of the University of Minho; ICVS (reference ICVS-SSRL: ON.2 SR&TD Integrated Program); Monocarboxylate transporters (MCTs) are vital for intracellular pH homeostasis by extruding lactate from highly glycolytic cells. T...
Phospho-mTOR in non-tumour and tumour bladder urothelium: Pattern of expression...
Afonso, Julieta; Longatto-Filho, Adhemar [UNESP]; Da Silva, Vitor Moreira; Amaro, Teresina; Santos, Iucio L.Made available in DSpace on 2015-11-03T18:06:25Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-10-01. Added 1 bitstream(s) on 2015-11-04T10:13:22Z : No. of bitstreams: 1 WOS000342725400009.pdf: 652138 bytes, checksum: b4c7b188d4ab260cf65e7c3243e162c0 (MD5); Urothelial bladder carcinoma (UBC) is heterogeneous in its pathology and clinical behaviour. Evaluation of prognostic and predictive biomarkers is n...
Uma nova perspetiva no cuidar: competência emocional (CE) nos fisioterapeutas d...
Afonso, Julieta; Fernandes, António; Veiga-Branco, AugustaOs cuidados de saúde exigem competência, também nos conceitos do que, atualmente, se considera CE em atividade profissional. Verifica-se a importância de conhecer a componente emocional daqueles que prestam cuidados diretos aos utentes (Vilela, 2006; Agostinho e Arruda, 2010), nomeadamente de como os Fisioterapeutas das Unidades de Internamento da RNCCI vivenciam emoções, reconhecendo de que forma consideram qu...
Competência emocional (CE) nos fisioterapeutas da rede nacional de cuidados con...
Afonso, Julieta; Fernandes, António; Veiga-Branco, AugustaOs cuidados de saúde revelam a necessidade de se ser competente na área que diz respeito aos conceitos do que, atualmente, se considera CE dentro da atividade profissional. Verifica-se a importância de conhecer a componente emocional daqueles que prestam cuidados diretos aos utentes (Vilela, 2006; Agostinho e Arruda, 2010), nomeadamente de como os Fisioterapeutas das Unidades de Internamento da RNCCI vivenciam ...
Emotional competence in healthcare professionals: correlationaland and comparat...
Veiga-Branco, Augusta; Afonso, Julieta; Caetano, IsabelleEmotional competence in healthcare professionals: correlational and comparative research Introdution - The relevance of this first empirical research (to our knowledge) in Continued Care National Network (RCNN) context,emerge to understand the role of emotions in workplace (Austin, Dore & Donovan, 2008; Liu et al. 2008; Barsade, Ramarajan, Burack,2008), here, with ill people and great physical and psychological...
Competência emocional nos fisioterapeutas da rncci – estudo descritivo
Afonso, Julieta; Veiga-Branco, AugustaTorna-se fundamental conhecer a componente emocional daqueles que prestam cuidados directos aos utentes (Vilela, 2006; Agostinho, Arruda, 2010). Parte-se do construto de Competência Emocional (CE), (Bisquerra, 2002; Veiga Branco, 2004a, b) baseado no conceito teórico inicial de Inteligência Emocional (Salovey & Mayer, 1990), para compreender como os Fisioterapeutas da RNCCI vivenciam emoções em contexto laboral...