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Extracellular nucleotide metabolism in Leishmania: influence of adenosine in th...
Fietto, Juliana Lopes Rangel; Marques-da-Silva, Eduardo de Almeida; Oliveira, Jamile Camargos de; Figueiredo, Amanda Braga; Lima Júnior, Djalma de SouzaLeishmaniasis is a parasitic disease with a variety of clinical forms, which are related to the Leishmania species involved. In the murine model, Leishmania amazonensis causes chronic non-healing lesions in Leishmania braziliensis- or Leishmania major-resistant mouse strains. In this study, we investigated the involvement of the pathway of extracellular nucleotide hydrolysis, with special focus on the role of e...
The schistosomiasis spleenOME : unveiling the proteomic landscape of splenomega...
Cosenza Contreras, Miguel de Jesus; Castro, Renata Alves de Oliveira e; Mattei, Bruno; Campos, Jonatan Marques; Silva, Gustavo GonçalvesSchistosomiasis is a neglected parasitic disease that affects millions of people worldwide and is caused by helminth parasites from the genus Schistosoma. When caused by S. mansoni, it is associated with the development of a hepatosplenic disease caused by an intense immune response to the important antigenic contribution of adult worms and to the presence of eggs trapped in liver tissue. Although the importanc...
E-NTPDase (ecto-nucleoside triphosphate diphosphohydrolase) of Leishmania amazo...
Souza Vasconcellos, Raphael de; Gomes, Rodrigo Saar; Carvalho, Luana Cristina Faria de; Fietto, Juliana Lopes Rangel; Afonso, Luís Carlos CroccoLeishmania amazonensis, the causal agent of diffuse cutaneous leishmaniasis, is known for its ability to modulate the host immune response. Because a relationship between ectonucleotidase activity and the ability of Leishmania to generate injury in C57BL/6 mice has been demonstrated, in this study we evaluated the involvement of ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase) activity of L. amazonen...
Leishmania amazonensis-induced caMP triggered by adenosine a2B receptor is impo...
Figueiredo, Amanda Braga de; Testasicca, Miriam Conceição de Souza; Mineo, Tiago Wilson Patriarca; Afonso, Luís Carlos CroccoDifferently from others Leishmania species, infection by the protozoan parasite L. amazonensis is associated with a lack of antigen-specific T-cell responses. Dendritic cells (DC) are essential for the innate immune response and for directing the differentiation of T-helper lymphocytes. Previously, we showed that L. amazonensis infection impairs DC activation through the activation of adenosine A2B receptor, an...
The Antileishmanial Potential of C-3 Functionalized Isobenzofuranones against L...
Pereira, Wagner Luiz; Vasconcellos, Raphael de Souza; Mariotini-Moura, Christiane; Gomes, Rodrigo Saar; Firmino, Rafaela de CássiaLeishmaniases are diseases caused by protozoan parasites of the genus Leishmania. Clinically, leishmaniases range from cutaneous to visceral forms, with estimated global incidences of 1.2 and 0.4 million cases per year, respectively. The treatment of these diseases relies on multiple parenteral injections with pentavalent antimonials or amphotericin B. However, these pharmaceuticals are either too toxic or expe...
Involvement of the chemokine RANTES (CCL5) in resistance to experimental infect...
Santiago, Helton da Costa; Oliveira, Carolina Ferreira; Santiago, Luciana; Ferraz, Fernanda Oliveira; Souza, Daniele da Glória deThe expression and putative role of chemokines during infection with Leishmania major in mice were investigated. CCL5 expression correlates with resistance, and blockade of CCL5 rendered mice more susceptible to infection. CCL5 is part of the cascade of events leading to efficient parasite control in L. major infection.
Purinergic signaling and infection by Leishmania : a new approach to evasion of...
Figueiredo, Amanda Braga de; Testasicca, Miriam Conceição de Souza; Afonso, Luís Carlos CroccoInfection by protozoan parasites is part of the most common Tropical Neglected Diseases. In the case of leishmaniasis, several millions of people are at risk of contracting the disease. In spite of innumerous studies that elucidated the immune response capable of killing the parasite, the understanding of the evasion mechanisms utilized by the parasite to survive within the very cell responsible for its destruc...
E-NTPDase (ecto-nucleoside triphosphate diphosphohydrolase) of Leishmania amazo...
Gomes, Rodrigo Saar; Carvalho, Luana Cristina Faria; Vasconcellos, Raphael de Souza; Fietto, Juliana Lopes Rangel; Afonso, Luís Carlos CroccoLeishmania amazonensis, the causal agent of diffuse cutaneous leishmaniasis, is known for its ability to modulate the host immune response. Because a relationship between ectonucleotidase activity and the ability of Leishmania to generate injury in C57BL/6 mice has been demonstrated, in this study we evaluated the involvement of ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase) activity of L. amazonen...
Tailored antihypertensive drug therapy prescribed to older women attenuates cir...
Toledo, Juliana Oliveira; Moraes, Clayton Franco; Souza, Vinícius Carolino; Furioso, Audrey Cecília Tonet; Afonso, Luís Carlos Crocco; Córdova, CláudioObjective: To test the hypothesis that antihypertensive drug therapy produces anti-inflammatory effects in clinical practice, this study investigated circulating levels of selected proinflammatory mediators (interleukin-6 [IL-6], tumor necrosis factor-alpha [TNF-α], and interferon-γ [INF-γ]) in response to multivariate drug directions for blood pressure (BP) control. Methods: Prospective study involving 110 hyp...
Nanoemulsions loaded with amphotericin B : a new approach for the treatment of ...
Caldeira, Leila Rodrigues; Fernandes, Flaviana Ribeiro; Costa, Daniel Ferreira; Frezard, Frederic Jean Georges; Afonso, Luís Carlos CroccoThis work aimed to develop nanoemulsions (NE) containing cholesterol and Amphotericin B (AmB) evaluating the influence of a lipophilic amine (stearylamine; STE) on drug encapsulation efficiency (EE), cytotoxicity on macrophages and in vitro antileishmanial activity. The EE of AmB in NE was nearly 100% regardless of STE concentration. Stability studies showed that AmB-loaded NE with or without STE were stable re...