13 documents found, page 1 of 2
Burned-Out Testicular Tumour: An Unusual Presentation
Santos Sousa, Nuno; Santos-Sousa, Duarte; Miranda, Rafaela; Coutada, Andreia; Afonso, Mariana; Costa Martins, SimãoAlthough being relatively uncommon, testicular primary germ cell tumours represent most of testicular tumours in young and middle-aged men. Metastatic disease accounts for up to ten percent of initial presentation.A 31-year-old man presented with a two-week history worsening left lumbar pain radiating to the ipsilateral lower limb associated with claudication. The straight leg raise test was positive. Therapeut...
Abdominal Tumor Requiring Surgical Resection in a Young Patient with Neurofibro...
Costa, Victor; Spencer, Hirondina; Borges, Pamela; Afonso, Mariana; Santos, Catarina; Barbosa, Carla; Santos, Lúcio LaraNeurofibromatosis type 1 (NF1) is an autosomal dominant disorder that affects approximately 1 in 3000 births. Retroperitoneal tumors occur in 2%-5% of NF1 patients and pose diagnostic and therapeutic challenges. We report a 25-year-old male from Cape Verde with confirmed NF1 who presented with progressive abdominal pain and a 15 x 11 x 12 cm retroperitoneal mass in the left psoas muscle. He underwent a successf...
Retroperitoneal Extra-adrenal Myelolipoma: A Diagnostic Challenge with Patholog...
Samouco, Lúcia; Pinheiro Magalhães, Maria João; Afonso, MarianaMyelolipomas are benign tumors composed of adipocites and hematopoyetic cells, presenting in older addults. They commonly occur in the adrenal gland and less frequently in extra-adrenal locations. Their etilogy is unknown, but eventually related to adrenocorticotropic hormonal excess. Most extra-adrenal myelolipomas are detected incedentally on cross-sectional imaging, they have mature fat and radiologically ar...
Therapeutic Options in Neuro-Oncology
Afonso, Mariana; Brito, Maria AlexandraOne of the biggest challenges in neuro-oncology is understanding the complexity of central nervous system tumors, such as gliomas, in order to develop suitable therapeutics. Conventional therapies in malignant gliomas reconcile surgery and radiotherapy with the use of chemotherapeutic options such as temozolomide, chloroethyl nitrosoureas and the combination therapy of procarbazine, lomustine and vincristine. W...
SARS-CoV-2 air and surface contamination in residential settings
Correia, Gil; Rodrigues, Luís; Afonso, Mariana; Mota, Marta; Oliveira, Joana; Soares, Rui; Tomás, Ana Luísa; Reichel, Anna; Silva, Patrícia M.SARS-CoV-2 transmission occurs mainly indoors, through virus-laden airborne particles. Although the presence and infectivity of SARS-CoV-2 in aerosol are now acknowledged, the underlying circumstances for its occurrence are still under investigation. The contamination of domiciliary environments during the isolation of SARS-CoV-2-infected patients in their respective rooms in individual houses and in a nursing ...
Retroperitoneal liposarcomas surgical treatment: retrospective analysis of prog...
Sousa, Alexandre; Martins, Pedro; Afonso, Mariana; Conde, Sofia; Ferreira, Ana; Soares, Marta; Dinis, José; Videira, Flávio; Guimarães dos Santos, JoséIntroduction: Retroperitoneal soft tissue sarcomas have a wide range of histologic entities but they are frequently studied as a single disease. Being liposarcomas the most frequent histologic type, we’ve carried a retrospective analysis from a cohort of patients treated at a referral center to assess prognostic factors associated with demographic and therapeutic characteristics.Methods: A retrospective analysi...
Stewart-Treves Syndrome
Almeida Costa, Nuno; Afonso, MarianaGoals: To present and review the appearance of a rare case of lymphoedema secondary breast angiosarcoma (Stewart-Treves syndrome).Methods: Diagnostic computed tomography (CT) and magnetic resonance (MR) images and a specimen photograph are presented, with a clinical case discussion and a brief pathology description.Outcomes: Early diagnosis and prompt surgery are crucial to improve the poor prognosis of this tu...
Candida Extracellular Nucleotide Metabolism Promotes Neutrophils Extracellular ...
Afonso, Mariana; Mestre, Ana Rita; Silva, Guilherme; Almeida, Ana Catarina; Cunha, Rodrigo A.; Meyer-Fernandes, José Roberto; Gonçalves, TeresaHost innate immunity is fundamental to the resistance against Candida albicans and Candida glabrata infection, two of the most important agents contributing to human fungal infections. Phagocytic cells, such as neutrophils, constitute the first line of host defense mechanisms, and the release of neutrophil extracellular traps (NETs) represent an important strategy to immobilize and to kill invading microorganis...
Case Report: Pheochromocytoma and Synchronous Neuroblastoma in a Family With He...
Duarte, Diana Borges; Ferreira, Lia; Santos, Ana P.; Costa, Cláudia; Lima, Jorge; Santos, Catarina; Afonso, Mariana; Teixeira, Manuel R.; Carvalho, RuiIntroduction: Pheochromocytomas are rare catecholamine-producing neuroendocrine tumours arising from chromaffin cells of the adrenal medulla or extra-adrenal sympathetic paraganglia. Recent studies have indicated that up to 40% of pheochromocytomas could be attributable to an inherited germline variant in an increasing list of susceptibility genes. Germline variants of the MYC-associated factor (MAX) gene have ...
DEEP VENOUS THROMBOSIS AS THE FIRST MANIFESTATION OF HIBERNOMA - CLINICAL CASE
Mesquita, Ana; Vidoedo, José; Maia, Miguel; Canotilho, Rita; Afonso, MarianaWe present a 36 year-old female patient with a popliteo-femoral deep vein thrombosis whose further workup revealed a thigh tumor later diagnosed as hibernoma. Hibernoma is a very rare benign tumor stemming from vestigial remnants of fetal brown adipose cells, usually disclosed as a slow and painless growing, mass. It is impossible to distinguish it on clinical grounds from the more aggressive and ominous liposa...