7 documents found, page 1 of 1
BISPECTRAL INDEX VALUES IN A BRAIN DEAD PATIENT – CASE REPORT
Afonso, Martax; x
Adiponectin, Leptin, and IGF-1 are useful diagnostic and stratification biomark...
Marques, Vanda; Afonso, Marta; Bierig, Nina; Duarte-Ramos, Filipa; Santos-Laso, Álvaro; Jimenez-Agüero, Raul; Eizaguirre, Emma; Bujanda, LuisBackground: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease where liver biopsy remains the gold standard for diagnosis. Here we aimed to evaluate the role of circulating adiponectin, leptin, and insulin-like growth factor 1 (IGF-1) levels as non-invasive NAFLD biomarkers and assess their correlation with the metabolome. Materials and Methods: Leptin, adiponectin, and IGF-1 seru...
Phenolic Profile Characterization of ‘Galega Vulgar’ and ‘Cobrançosa’ Portugues...
Ferro, Miguel D.; Lopes, Elsa; Afonso, Marta; Peixe, Augusto; Rodrigues, Francisco M.; Duarte, Maria F.The phenolic composition of olive fruits represents a vast and unique source of health beneficial molecules due to the presence of specific phenolic compounds (PCs), such as verbascoside (VERB), oleuropein (OLE) and its derivative molecules. Despite of being some of the most critical compounds regarding olive oil quality, these PCs are mostly abundant in olive fruits and leafs due to their hydrophilic nature. I...
Combining 1,3-ditriazolyl-benzene and quinoline to discover a new G-quadruplex ...
Mendes, Maria Eduarda; Cadoni, Enrico; Carneiro, Filipa; Afonso, Marta; Brito, Hugo; Lavrado, João; Santos, Daniel J. V. A. dos; Vítor, Jorge M. B.Quadruplex nucleic acids are promising targets for cancer therapy. In this study we used a fragment-based approach to create new flexible G-quadruplex (G4) DNA-interactive small molecules with good calculated oral drug-like properties, based on quinoline and triazole heterocycles. G4 melting temperature and polymerase chain reaction (PCR)-stop assays showed that two of these compounds are selective G4 ligands, ...
Targeting hepatocyte necroptosis to treat liver diseases
Afonso, MartaChronic liver diseases are considered a major public health concern, and their prevalence and incidence are increasing with serious long-term implications, such as cirrhosis, hepatocellular carcinoma (HCC) and, ultimately, premature death. In particular, non-alcoholic fatty liver disease (NAFLD) and chronic cholestatic liver disease are two distinct pathologic conditions sharing a progressive nature and lacking...
Activation of necroptosis in human and experimental cholestasis
Afonso, Marta; Rodrigues, Pedro; Simão, André; Ofengeim, Dimitry; Carvalho, Tânia; Amaral, Joana D.; Gaspar, Maria Manuela; Cortez-Pinto, HelenaCholestasis encompasses liver injury and inflammation. Necroptosis, a necrotic cell death pathway regulated by receptor-interacting protein (RIP) 3, may mediate cell death and inflammation in the liver. We aimed to investigate the role of necroptosis in mediating deleterious processes associated with cholestatic liver disease. Hallmarks of necroptosis were evaluated in liver biopsies of primary biliary cholangi...
o corpo feminino na ilustração científica: uma reflexão visual em torno de conv...
Afonso, MartaA presente dissertação reflete acerca da representação visual do corpo feminino nas ilustrações científicas. Através de uma análise às convenções e aos padrões de representação, descobrem-se narrativas socioculturais associadas ao modo de pensar a mulher e o seu corpo numa sociedade de cariz patriarcal. Recorrendo ao design de comunicação como meio de observação, reflexão e crítica, concebe-se uma plataforma on...