2 documents found, page 1 of 1
Disclosing the antitumour potential of the marine bromoditerpene sphaerococceno...
Alves, Celso; Silva, Joana; Afonso, Marta B; Guedes, Romina A.; Guedes, Rita C.; Alvariño, Rebeca; Pinteus, Susete; Gaspar, Helena; Goettert, Márcia I.Nature has revealed to be a key source of innovative anticancer drugs. This study evaluated the antitumour potential of the marine bromoditerpene sphaerococcenol A on different cancer cellular models. Dose-response analyses (0.1-100 µM; 24 h) were accomplished in eight different tumour cell lines (A549, CACO-2, HCT-15, MCF-7, NCI-H226, PC-3, SH-SY5Y, SK-MEL-28). Deeper studies were conducted on MFC-7 cells, nam...
Inhibition of receptor-interacting protein kinase 1 improves experimental non-a...
Majdi, Amine; Aoudjehane, Lynda; Ratziu, Vlad; Islam, Tawhidul; Afonso, Marta B; Conti, Filomena; Mestiri, Taïeb; Lagouge, Marie; Foufelle, FabienneIn non-alcoholic fatty liver disease (NAFLD), hepatocytes can undergo necroptosis: a regulated form of necrotic cell death mediated by the receptor-interacting protein kinase (RIPK) 1. Herein, we assessed the potential for RIPK1 and its downstream effector mixed lineage kinase domain-like protein (MLKL) to act as therapeutic targets and markers of activity in NAFLD.