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Tapentadol prevents motor impairments in a mouse model of dyskinesia

Vaz, Rita; Chapela Pires, Diana; Coelho, Joana E; Lopes, Luisa V.; Ferreira, Joaquim J; Afonso, Nuno D.; Sousa, Sara; Outeiro, Tiago

The motor features in Parkinson's disease (PD) are associated with the degeneration of dopaminergic cells in the substantia nigra in the brain. Thus, the gold-standard in PD therapeutics still consists of dopamine replacement with levodopa. However, as the disease progresses, this therapeutic option becomes less effective and can be accompanied by levodopa-induced complications. On the other hand, several other...

Date: 2020   |   Origin: Repositório da Universidade de Lisboa
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