146 documents found, page 1 of 15
Predicting red blood cell transfusion in elective cardiac surgery: a machine le...
Lau, Beatriz; Ramos, Daniel; Afreixo, Vera; Silva, Luís M.; Tavares, Ana Helena; Felgueiras, Miguel Martins; Paupério, Diana CastroThe benefits of Patient Blood Management can vary depending on a patient’s risk profile for requiring a blood transfusion. The objective of this study is to develop and analyse machine learning models that can identify patients at risk of requiring red blood cell transfusion. This retrospective cohort study was conducted at a tertiary northern Portuguese hospital between 2018 and 2023. Two machine learning algo...
Effectiveness of specific scapular therapeutic exercises in patients with shoul...
Melo, Ana; Moreira, Juliana; Afreixo, Vera; Gonçalves, Daniel Moreira; Donato, Helena; Cruz, Eduardo B.; Vilas-Boas, J. Paulo; Sousa, AndreiaTherapeutic exercise has been considered a useful tool to rehabilitate shoulder pain, namely through its influence on scapular dynamics. Accordingly, the effectiveness of scapular therapeutic exercise needs to be explored. The present study aims to evaluate the effectiveness of scapular therapeutic exercises in shoulder pain and to identify the most effective exercise type (focal or multijoint) and ways of deli...
Polypharmacy and drug interactions in older patients with cancer receiving chem...
Ferraz Oliveira, Rita; Oliveira, Ana Isabel; Cruz, Agostinho; Ribeiro, Oscar; Afreixo, Vera; Pimentel, FranciscoPolypharmacy in older adults with cancer receiving chemotherapy leads to increased risks of drug interactions, translating in potential hazardous health outcomes. This study aims to assess the prevalence of polypharmacy, drug–drug interactions (DDIs), and severe-drug interactions (SDIs) in older patients with cancer. Antineoplastic agents (ANAs) involvement and possible risk contexts (comorbidities with cardiac...
Comparison of feature selection methods: modelling COPD outcomes
Cabral, Jorge; Macedo, Pedro; Marques, Alda; Afreixo, VeraSelecting features associated with patient-centered outcomes is of major relevance yet the importance given depends on the method. We aimed to compare stepwise selection, least absolute shrinkage and selection operator, random forest, Boruta, extreme gradient boosting and generalized maximum entropy estimation and suggest an aggregated evaluation. We also aimed to describe outcomes in people with chronic obstru...
Stable variable selection method with shrinkage regression applied to the selec...
Afreixo, Vera; Tavares, Ana Helena; Enes, Vera; Pinheiro, Miguel; Rodrigues, Leonor; Moura, GabrielaIn this work, we aimed to establish a stable and accurate procedure with which to perform feature selection in datasets with a much higher number of predictors than individuals, as in genomewide association studies. Due to the instability of feature selection where many potential predictors are measured, a variable selection procedure is proposed that combines several replications of shrinkage regression models...
Descriptive Analysis of Adverse Drug Reactions Reports of the Most Consumed Ant...
Ferreira, Joana; Plácido, Ana; Afreixo, Vera; Ribeiro-Vaz, Inês; Roque, Fátima; Herdeiro, MariaAdverse drug reactions (ADR) significantly impact mortality and morbidity and lead to high healthcare costs. Reporting ADR to regulatory authorities allows for monitoring the safety and efficacy profile of medicines on the market and for assessing the benefit-risk ratio. This retrospective study aims to characterize the ADR profile of the most consumed antibiotics in Portugal that are prescribed for upper airwa...
Impacto da COVID-19 na incidência de hospitalizações por lesões autoinfligidas ...
Cardoso, Catarina; Silva, Susana; Alves, Tatiana; Nunes, Baltazar; Afreixo, VeraCom o início da pandemia de COVID-19, a realidade até então conhecida mudou para muitas pessoas. A falta de convivência com familiares e amigos, insegurança, ansiedade, medo de contrair a infeção, problemas económicos decorrentes da pandemia e luto pelos familiares e amigos que perderam e dos quais não se puderam despedir devido às restrições, podem aumentar os riscos para a saúde mental e consequentemente para...
A multiobjective optimization approach to pulmonary rehabilitation effectivenes...
Cabral, Jorge; Afreixo, Vera; Silva, Cristiana J.; Tavares, Ana Helena; Marques, AldaChronic obstructive pulmonary disease (COPD) is a common disease that accounts for a significant individualand societal burden. Pulmonary rehabilitation (PR) is a key management strategy but it is highly inaccessible, makingprioritisation highly needed. This study aimed to determine and optimize predictive models of PR outcomes and builda tool to help healthcare professionals in their clinical decision-making a...
Concentration of inverted repeats along human DNA
Bastos, Carlos A. C.; Afreixo, Vera; Rodrigues, João M. O. S.; Pinho, Armando J.This work aims to describe the observed enrichment of inverted repeats in the human genome; and to identify and describe, with detailed length profiles, the regions with significant and relevant enriched occurrence of inverted repeats. The enrichment is assessed and tested with a recently proposed measure (z-scores based measure). We simulate a genome using an order 7 Markov model trained with the data from the...
Acute kidney injury after endovascular therapy in acute stroke patients: system...
Oliveira, Marta; Rocha, Ana; Barbosa, Flávia; Barros, Pedro; Almeida, Luísa; Ribeiro, Manuel; Afreixo, Vera; Gregório, TiagoAims Endovascular therapy (EVT) is a highly effective stroke treatment, but it requires the administration of contrast media which puts patients at risk of acute kidney injury (AKI). AKI is associated with increased morbidity and mortality in cardiovascular patients. Methods PubMed, Scopus, ISI and the Cochrane Library were systematically searched for observational and experimental studies assessing the occurre...