142 documents found, page 1 of 15
Stable variable selection method with shrinkage regression applied to the selec...
Afreixo, Vera; Tavares, Ana Helena; Enes, Vera; Pinheiro, Miguel; Rodrigues, Leonor; Moura, GabrielaIn this work, we aimed to establish a stable and accurate procedure with which to perform feature selection in datasets with a much higher number of predictors than individuals, as in genomewide association studies. Due to the instability of feature selection where many potential predictors are measured, a variable selection procedure is proposed that combines several replications of shrinkage regression models...
Descriptive Analysis of Adverse Drug Reactions Reports of the Most Consumed Ant...
Ferreira, Joana; Plácido, Ana; Afreixo, Vera; Ribeiro-Vaz, Inês; Roque, Fátima; Herdeiro, MariaAdverse drug reactions (ADR) significantly impact mortality and morbidity and lead to high healthcare costs. Reporting ADR to regulatory authorities allows for monitoring the safety and efficacy profile of medicines on the market and for assessing the benefit-risk ratio. This retrospective study aims to characterize the ADR profile of the most consumed antibiotics in Portugal that are prescribed for upper airwa...
Impacto da COVID-19 na incidência de hospitalizações por lesões autoinfligidas ...
Cardoso, Catarina; Silva, Susana; Alves, Tatiana; Nunes, Baltazar; Afreixo, VeraResumo publicado em Gaceta sanitária: Gac Sanit. 2023;37(Issue S1): S242. https://www.gacetasanitaria.org/es-pdf-X0213911123036410?local=true; Com o início da pandemia de COVID-19, a realidade até então conhecida mudou para muitas pessoas. A falta de convivência com familiares e amigos, insegurança, ansiedade, medo de contrair a infeção, problemas económicos decorrentes da pandemia e luto pelos familiares e ami...
A multiobjective optimization approach to pulmonary rehabilitation effectivenes...
Cabral, Jorge; Afreixo, Vera; Silva, Cristiana J.; Tavares, Ana Helena; Marques, AldaChronic obstructive pulmonary disease (COPD) is a common disease that accounts for a significant individualand societal burden. Pulmonary rehabilitation (PR) is a key management strategy but it is highly inaccessible, makingprioritisation highly needed. This study aimed to determine and optimize predictive models of PR outcomes and builda tool to help healthcare professionals in their clinical decision-making a...
Concentration of inverted repeats along human DNA
Bastos, Carlos A. C.; Afreixo, Vera; Rodrigues, João M. O. S.; Pinho, Armando J.This work aims to describe the observed enrichment of inverted repeats in the human genome; and to identify and describe, with detailed length profiles, the regions with significant and relevant enriched occurrence of inverted repeats. The enrichment is assessed and tested with a recently proposed measure (z-scores based measure). We simulate a genome using an order 7 Markov model trained with the data from the...
Acute kidney injury after endovascular therapy in acute stroke patients: system...
Oliveira, Marta; Rocha, Ana; Barbosa, Flávia; Barros, Pedro; Almeida, Luísa; Ribeiro, Manuel; Afreixo, Vera; Gregório, TiagoAims Endovascular therapy (EVT) is a highly effective stroke treatment, but it requires the administration of contrast media which puts patients at risk of acute kidney injury (AKI). AKI is associated with increased morbidity and mortality in cardiovascular patients. Methods PubMed, Scopus, ISI and the Cochrane Library were systematically searched for observational and experimental studies assessing the occurre...
Effects of a physical exercise program on quality of life and physical fitness ...
Joaquim, Ana; Amarelo, Anabela; Antunes, Pedro; Garcia, Catarina; Leão, Inês; Vilela, Eduardo; Teixeira, Madalena; Duarte, Bárbara; Vieira, MicaelTo assess the effects of a group class physical exercise program on health-related quality of life (HRQOL), physical fitness and activity, and safety in early breast cancer women after treatment, a double phase trial [16-week control phase (CP) followed by a 16-week intervention phase (IP)] was designed. Outcomes were evaluated at baseline (T1), 8 (T2) and 16 (T3) weeks (CP), and 24 (T4) and 32 (T5) weeks (IP)....
Analysis of potential risk factors for multidrug-resistance at a burn unit
Cabral, Luís; Rodrigues, Leonor; Tavares, Ana Helena; Tomé, Gonçalo; Caetano, Marisa; Chaves, Catarina; Afreixo, VeraBackground: Infections by multidrug-resistant (MDR) microorganisms are associated with increased morbidity and mortality in burn patients. This study aimed to analyze the evolution of MDR bacteria over a five-year period at Coimbra Burns Unit (CBU) in Portugal, seeking to assess the possible associations of specific bacteria with presumed risk factors. Methods: The data obtained consisted of identified bacteria...
Evaluating COVID-19 in Portugal: Bootstrap confidence interval
Tedim, Sofia; Afreixo, Vera; Felgueiras, Miguel; Leitão, Rui Pedro; Pinheiro, Sofia J.; Silva, Cristiana J.In this paper, we consider a compartmental model to fit the real data of confirmed active cases with COVID-19 in Portugal, from March 2, 2020 until September 10, 2021 in the Primary Care Cluster in Aveiro region, ACES BV, reported to the Public Health Unit. The model includes a deterministic component based on ordinary differential equations and a stochastic component based on bootstrap methods in regression. T...
Genetic predisposition for low functional status in COPD
Marçalo, Rui; Rodrigues, Guilherme; Pinheiro, Miguel; Neto, Sonya; Marques, Sofia L.; Simão, Paula; Martins, Vitória; Andrade, LíliaSem resumo disponível.