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Fibroblasts Impair Migration and Antitumor Activity of NK-92 Lymphocytes in a M...
Iaia, Ilenia; Brancato, Virginia; Caballero, David; Reis, R. L.; Aglietta, Massimo; Sangiolo, Dario; Kundu, Subhas CAdoptive cell therapy in solid tumors, such as melanoma, is impaired, but little is known about the role that the fibroblasts present in the tumor microenvironment could exert. However, the mechanism at play is not well understood, partly due to the lack of relevant pre-clinical models. Three-dimensional culture and microfluidic chips are used to recapitulate the dynamic interactions among different types of ce...
Date: 2023
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Origin: RepositóriUM - Universidade do Minho