20 documents found, page 1 of 2
Escala de interações enfermeiro- paciente
Agostinho, Paula; Mendes Gaspar, Maria Filomena; Potra, TeresaA escala multidimensional L´Échelle d´Interactions Infirmière-Patient-23 (EIIP-23) é usada para avaliar e compreender as perceções dos enfermeiros sobre as suas intervenções na prática de cuidados, para alcançar melhores resultados de saúde. A versão portuguesa da EIEP apresenta uma estrutura com 22 itens distribuídos por 3 dimensões (Cuidados Relacionais, Cuidados Clínicos e Cuidados de Conforto), que explicou...
Astrocytes and Adenosine A2A Receptors: Active Players in Alzheimer's Disease
Lopes, Cátia R.; Cunha, Rodrigo A.; Agostinho, PaulaAstrocytes, through their numerous processes, establish a bidirectional communication with neurons that is crucial to regulate synaptic plasticity, the purported neurophysiological basis of memory. This evidence contributed to change the classic "neurocentric" view of Alzheimer's disease (AD), being astrocytes increasingly considered a key player in this neurodegenerative disease. AD, the most common form of de...
Crosstalk Between ATP-P2X7 and Adenosine A2A Receptors Controlling Neuroinflamm...
Dias, Liliana; Lopes, Cátia R.; Gonçalves, Francisco Q.; Nunes, Ana R.; Pochmann, Daniela; Machado, Nuno J.; Tomé, Ângelo R.; Agostinho, PaulaDepressive conditions precipitated by repeated stress are a major socio-economical burden in Western countries. Previous studies showed that ATP-P2X7 receptors (P2X7R) and adenosine A2A receptors (A2AR) antagonists attenuate behavioral modifications upon exposure to repeated stress. Since it is unknown if these two purinergic modulation systems work independently, we now investigated a putative interplay betwee...
Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Tr...
Canas, Paula M.; Porciúncula, Lisiane O.; Simões, Ana Patrícia; Augusto, Elisabete de Oliveira; Silva, Henrique B.; Machado, Nuno J.; Gonçalves, NélioNeurodegeneration is a process transversal to neuropsychiatric diseases and the understanding of its mechanisms should allow devising strategies to prevent this irreversible step in brain diseases. Neurodegeneration caused by seizures is a critical step in the aggravation of temporal lobe epilepsy, but its mechanisms remain undetermined. Convulsions trigger an elevation of extracellular adenosine and upregulate...
Caffeine reverts memory but not mood impairment in a depression-prone mouse str...
Machado, Nuno J.; Simoes, Ana Patricia; Silva, Henrique B.; Ardais, Ana Paula; Kaster, Manuella P.; Garcao, Pedro; Rodrigues, Diana I.Caffeine prophylactically prevents mood and memory impairments through adenosine A(2A) receptor (A(2A)R) antagonism. A(2A)R antagonists also therapeutically revert mood and memory impairments, but it is not known if caffeine is also therapeutically or only prophylactically effective. Since depression is accompanied by mood and memory alterations, we now explored if chronic (4 weeks) caffeine consumption (0.3 g/...
Oncostatin M promotes excitotoxicity by inhibiting glutamate uptake in astrocyt...
Moidunny, Shamsudheen; Matos, Marco; Wesseling, Evelyn; Banerjee, Santanu; Volsky, David J.; Cunha, Rodrigo A.; Agostinho, Paula; Boddeke, Hendrikus W.Background: Elevated levels of oncostatin M (OSM), an interleukin-6 cytokine family member, have been observed in HIV-1-associated neurocognitive disorders (HAND) and Alzheimer’s disease. However, the function of OSM in these disease conditions is unclear. Since deficient glutamate uptake by astrocytes is instrumental in HAND-associated neurotoxicity, we hypothesized that OSM impairs glutamate uptake in astrocy...
Depression as a Glial-Based Synaptic Dysfunction
Rial, Daniel; Lemos, Cristina; Pinheiro, Helena; Duarte, Joana M.; Gonçalves, Francisco Q.; Real, Joana I.; Prediger, Rui D.; Gonçalves, NélioRecent studies combining pharmacological, behavioral, electrophysiological and molecular approaches indicate that depression results from maladaptive neuroplastic processes occurring in defined frontolimbic circuits responsible for emotional processing such as the prefrontal cortex, hippocampus, amygdala and ventral striatum. However, the exact mechanisms controlling synaptic plasticity that are disrupted to tr...
Does caffeine consumption modify cerebrospinal fluid amyloid-β levels in patien...
Travassos, Maria; Santana, Isabel; Baldeiras, Inês; Tsolaki, Magda; Gkatzima, Olymbia; Sermin, Genc; Yener, Görsev G.; Simonsen, AnjaCaffeine may be protective against Alzheimer's disease (AD) by modulating amyloid-β (Aβ) metabolic pathways. The present work aimed to study a possible association of caffeine consumption with the cerebrospinal fluid (CSF) biomarkers, particularly Aβ. The study included 88 patients with AD or mild cognitive impairment. The consumption of caffeine and theobromine was evaluated using a validated food questionnair...
Anthocyanins restore behavioral and biochemical changes caused by streptozotoci...
Gutierres, Jessié M.; Carvalho, Fabiano B.; Schetinger, Maria Rosa C.; Marisco, Patrícia; Agostinho, Paula; Rodrigues, Marília; Rubin, Maribel A.Aims The aim of this study was to analyze if the pre-administration of anthocyanin on memory and anxiety prevented the effects caused by intracerebroventricular streptozotocin (icv-STZ) administration-induced sporadic dementia of Alzheimer's type (SDAT) in rats. Moreover, we evaluated whether the levels of nitrite/nitrate (NOx), Na+,K+-ATPase, Ca2 +-ATPase and acethylcholinesterase (AChE) activities in the cere...
Neuroprotective effect of anthocyanins on acetylcholinesterase activity and att...
Gutierres, Jessié M.; Carvalho, Fabiano B.; Schetinger, Maria Rosa C.; Agostinho, Paula; Marisco, Patricia C.; Vieira, Juliano M.; Rosa, Michele M.Anthocyanins are a group of natural phenolic compounds responsible for the color to plants and fruits. These compounds might have beneficial effects on memory and have antioxidant properties. In the present study we have investigated the therapeutic efficacy of anthocyanins in an animal model of cognitive deficits, associated to Alzheimer's disease, induced by scopolamine. We evaluated whether anthocyanins prot...