8 documents found, page 1 of 1
Increased Synaptic ATP Release and CD73-Mediated Formation of Extracellular Ade...
Dias, Liliana; Pochmann, Daniela; Lemos, Cristina; Silva, Henrique B.; Real, Joana I.; Gonçalves, Francisco Q.; Rial, Daniel; Gonçalves, NélioIncreased ATP release and its extracellular catabolism through CD73 (ecto-5'-nucleotidase) lead to the overactivation of adenosine A2A receptors (A2AR), which occurs in different brain disorders. A2AR blockade blunts mood and memory dysfunction caused by repeated stress, but it is unknown if increased ATP release coupled to CD73-mediated formation of extracellular adenosine is responsible for A2AR overactivatio...
Downregulation of Sirtuin 1 Does Not Account for the Impaired Long-Term Potenti...
Lopes, Cátia R.; Silva, Joana S; Santos, Joana; Rodrigues, Matilde S.; Madeira, Daniela; Oliveira, Andreia; Moreira-de-Sá, Ana; Lourenço, Vanessa S.Alzheimer's disease (AD), which predominantly affects women, involves at its onset a metabolic deregulation associated with a synaptic failure. Here, we performed a behavioral, neurophysiological and neurochemical characterization of 9-month-old female APPswe/PS1dE9 (APP/PS1) mice as a model of early AD. These animals showed learning and memory deficits in the Morris water maze, increased thigmotaxis and anxiet...
Effects of Chronic Caffeine Consumption on Synaptic Function, Metabolism and Ad...
Lopes, Cátia R.; Oliveira, Andreia; Gaspar, Ingride L.; Rodrigues, Matilde S.; Santos, Joana; Szabó, Eszter; Silva, Henrique B.; Tomé, Ângelo R.Adenosine receptors mainly control synaptic function, and excessive activation of adenosine receptors may worsen the onset of many neurological disorders. Accordingly, the regular intake of moderate doses of caffeine antagonizes adenosine receptors and affords robust neuroprotection. Although caffeine intake alters brain functional connectivity and multi-omics analyses indicate that caffeine intake modifies syn...
Adenosine A2A Receptor Up-Regulation Pre-Dates Deficits of Synaptic Plasticity ...
Lopes, Cátia R.; Silva, Antonio C.; Silva, Henrique B.; Canas, Paula M.; Agostinho, Paula M.; Cunha, Rodrigo A.; Lopes, João PedroThe intracerebroventricular (icv) injection of amyloid peptides (Aβ) models Alzheimer's disease (AD) in mice, as typified by the onset within 15 days of deficits of memory and of hippocampal long-term potentiation (LTP) that are prevented by the blockade of adenosine A2A receptors (A2AR). Since A2AR overfunction is sufficient to trigger memory deficits, we tested if A2AR were upregulated in hippocampal synapses...
Caffeine consumption prevents diabetes-induced memory impairment and synaptotox...
Duarte, João M. N.; Agostinho, Paula M.; Carvalho, Rui A.; Cunha, Rodrigo A.Diabetic conditions are associated with modified brain function, namely with cognitive deficits, through largely undetermined processes. More than understanding the underlying mechanism, it is important to devise novel strategies to alleviate diabetes-induced cognitive deficits. Caffeine (a mixed antagonist of adenosine A(1) and A(2A) receptors) emerges as a promising candidate since caffeine consumption reduce...
Enhanced role of adenosine A2A receptors in the modulation of LTP in the rat hi...
Costenla, Ana Rita; Diógenes, Maria José; Canas, Paula M.; Rodrigues, Ricardo J.; Nogueira, Célia; Marôco, João; Agostinho, Paula M.Adenosine neuromodulation depends on a balanced activation of inhibitory A₁ (A₁R) and facilitatory A(₂A) receptors (A(₂A) R). Both A₁ R and A(₂A) R modulate hippocampal glutamate release and NMDA-dependent long-term potentiation (LTP) but ageing affects the density of both A₁ R and A(₂A) R. We tested the effects of selective A₁ R and A(2A) R antagonists in the modulation of synaptic transmission and plasticity ...
Enhanced role of adenosine A2A receptors in the modulation of LTP in the rat hi...
Costenla, Ana R.; Diógenes, Maria J.; Canas, Paula M.; Rodrigues, Ricardo J.; Nogueira, Célia; Maroco, João; Agostinho, Paula M.; Ribeiro, Joaquim A.Adenosine neuromodulation depends on a balanced activation of inhibitory A1 (A1R) and facilitatory A2A receptors (A2AR). Both A1R and A2AR modulate hippocampal glutamate release and NMDA-dependent long-term potentiation (LTP) but ageing affects the density of both A1R and A2AR. We tested the effects of selective A1R and A2AR antagonists in the modulation of synaptic transmission and plasticity in rat hippocampa...
Glutamate in Life and Death of Retinal Amacrine Cells*
Duarte, Carlos B.; Ferreira, Ildete L.; Santos, Paulo F.; Carvalho, Ana L.; Agostinho, Paula M.; Carvalho, Arsélio P.1. Glutamate is the neurotransmitter released by bipolar cells at their synapses with amacrine cells. The amacrine cells express ionotropic (NMDA, AMPA and kainate) and metabotropic (mGluR1, mGluR2, mGluR4 and mGluR7) glutamate receptors and may take up glutamate from the synaptic cleft.; http://www.sciencedirect.com/science/article/B6T71-3WDCGNH-6/1/585429baef39660288a51842ff1b4c33