63 documents found, page 1 of 7
A genetic variant in the 3′-UTR of PIWIL4 confers risk for extreme phenotypes o...
González-Muñoz, Sara; Cerván-Martín, Miriam; Guzmán-Jiménez, Andrea; Rodríguez-Martín, Ana Isabel; Garrido, Nicolás; Castilla, José A.Study question: What is the functional impact of the rs508485 genetic polymorphism, located in the 3'-untranslated region (UTR) region of the PIWIL4 gene, on non-obstructive azoospermia (NOA)? Summary answer: The rs508485 genetic variant contributes to the pathogenesis of extreme patterns of NOA by modulating PIWIL4 expression through microRNA (miRNA) interactions. What is known already: Male infertility repres...
European guidelines for the management of tuberculosis screening procedures in ...
Pinheiro, Marina; Valente, Carolina; Cruz, Margarida; Nascimento Moreira, David; Aguiar, Ana; Duarte, RaquelBackground: This systematic review assesses the current available evidence across the WHO European region on the effectiveness and cost-effectiveness of the different approaches used for TB screening and also explores the facilitators and barriers that migrants face during screening programmes. Methods: We conducted an extensive, comprehensive, and systematic literature search across multiple databases, includi...
Expert perspectives on tuberculosis screening procedures for migrants
Pinheiro, Marina; Moreira, David N.; Aguiar, Ana; Duarte, RaquelObjective: To evaluate the perspectives of tuberculosis experts from different countries regarding national screening procedures. Methods: This was a qualitative descriptive study. Data were collected by using electronic, anonymized surveys with experts in tuberculosis in seven different countries within two World Health Organization regions (Europe and Africa). Thematic analysis was employed. Results: The surv...
Optimising non-pharmacological interventions in people with non-tuberculous myc...
Sulaiman, Naif; Martins, Beatriz; Moreira-Sousa, Diana; Aguiar, Ana; Hurst, John R.; Brown, James; Duarte, Raquel; Lipman, MarcIntroduction: Treatment of non-tuberculous mycobacterial pulmonary disease (NTM-PD) is often complex, relying on long treatment courses with multiple antibiotics, which are associated with treatment intolerance and failure. Current guidelines provide limited insight into non-pharmacological treatment, which is believed to be an important component of symptom control and is related to treatment outcomes with an ...
Safety, Efficacy, and Pharmacokinetics of Daily Optimized Doses of Rifampicin f...
Espinosa-Pereiro, Juan; Aguiar, Ana; Nara, Eva; Medina, Angelica; Molinas, Gladys; Tavares, Margarida; Tortola, Teresa; Ghimire, SamikshaBackground: Higher than standard doses of rifampicin could improve the treatment outcome of drug-susceptible tuberculosis (TB) without compromising the safety of patients. Methods: We performed a systematic review of prospective clinical studies including adults with pulmonary and extrapulmonary TB receiving rifampicin doses above 10 mg/kg/day. We extracted the data on overall adverse events (AE), hepatic AE, s...
The Invisible Face of COVID-19
Duarte, Raquel; Aguiar, AnaExtract: The COVID-19 pandemic has left indelible marks on the global landscape, disrupting lives, economies, and health systems. The immediate, visible consequences of the pandemic include overwhelmed healthcare systems, with hospitals stretched beyond capacity, leading to delayed care and strained resources¹,². Staggering mortality rates became a grim hallmark as COVID-19 claimed millions of lives worldwide. ...
A multinational Delphi consensus on tuberculosis screening of migrants in Europe
Pinheiro, Marina; Aguiar, Ana; Moreira, David N.; Akkerman, Onno W.; Al-Suwaidi, Zubaida; Alffenaar, Jan-Willem C.; Arandjelović, Irena; Brito, UlissesThe disproportionate burden of tuberculosis among migrants in the World Health Organization (WHO) European Region underscores the urgent need to address the public health challenges associated with global migration. Recommendations for screening of pulmonary tuberculosis (TB) and TB infection (TBI) are highly variable across European countries, highlighting the need for standardised practices and coordinated ef...
Adapting to COVID-19: Insights from Portuguese residents' home-based life
Aguiar, Ana; Soares, Patricia; Barbosa, Pedro; Duarte, Raquel; Pinto, MartaBackground: The COVID-19 pandemic led to widespread lockdowns and remote work and educational practices that have impacted the lives of many families. Objective: We aimed to investigate how parents and caregivers altered their routines due to online schooling and teleworking, exploring their association with increased anxiety and depression symptoms. Methods: We conducted an online cross-sectional study and col...
Urgent Attention Needed for Mental Health Challenges Arising from Prolonged Gri...
Aguiar, Ana; Pinto, Marta; Duarte, RaquelN/a.; N/a.
Anxiety and Depression Symptoms During the COVID-19 Pandemic: A Cluster Analysi...
Aguiar, Ana; Bezerra, Ana; Gaio, Rita; Pinto, Marta; Duarte, RaquelIntroduction: The COVID-19 pandemic is an illustration of how a physical illness can damage people’s minds. In this regard, the goal of this study was to see how different sociodemographic and behavioral factors were linked to anxiety and depression symptoms in a group of individuals living in Portugal. Methods: Between November 2020 and February 2021, a cross-sectional, snowball online study was conducted. The...