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Predictive Factors of Relapse After Methotrexate Discontinuation in Juvenile Id...

Azevedo, S; Tavares-Costa, J; Melo, AT; Freitas, R; Cabral, M; Conde, M; Aguiar, F; Neto, A; Mourão, AF; Oliveira-Ramos, F; Santos, MJ; Peixoto, D

Objective: To identify predictive factors of relapse after discontinuation of Methotrexate (MTX) in Juvenile Idiopathic Arthritis (JIA) patients with inactive disease. Methods: We conducted a prospective multicenter cohort study of patients diagnosed with JIA using real world data from the Portuguese national register database, Reuma.pt. Patients with JIA who have reached JADAS27 inactive disease and discontinu...


Kidney function, age, and education as contributors to depression and anxiety i...

Figueiredo-Braga, M; Silva, B; Ganhão, S; Aguiar, F; Cornaby, C; Brito, I; Poole, BD

Juvenile systemic lupus erythematosus (JSLE) is diagnosed in children younger than 18 years of age. Depression and anxiety are common, but not well understood in JSLE. We investi-gated the clinical and psychological factors associated with the psychological manifestations of JSLE. Twenty-nine JSLE patients were recruited for the study. Patients completed surveys evaluating their psychological status and percept...


The impact of indoor air quality on respiratory health of older people living i...

Belo, J; Carreiro-Martins, P; Papoila, AL; Palmeiro, T; Caires, I; Alves, M; Nogueira, S; Aguiar, F; Mendes, A; Cano, M; Botelho, MA; Neuparth, N

n the Portuguese Geriatric Study of the Health Effects of Indoor Air Quality in Senior Nursing Homes, we aimed to evaluate the impact of indoor air contaminants on the respiratory symptoms and biomarkers in a sample of elderly living in nursing homes. A total of 269 elderly answered a health questionnaire, performed a spirometry and 150 out of these collected an exhaled breath condensate sample for pH and nitri...


Overall Survival Analysis and Characterization of an EGFR Mutated Non-Small Cel...

Aguiar, F; Fernandes, G; Queiroga, H; Machado, JC; Cirnes, L; Souto Moura, C; Hespanhol, V

BACKGROUND: Patients with activating somatic mutations in the Epidermal Growth Factor Receptor (EGFR) have better clinical outcomes when treated with Tyrosine Kinase Inhibitors (TKI) over chemotherapy. However, the impact of the use of TKIs on overall survival outside clinical trials is not well established. OBJECTIVE: To characterize and analyze the overall survival of a Caucasian population with NSCLC and EGF...


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