4 documents found, page 1 of 1
Doença Hemolítica do Recém-Nascido - Frequência de anticorpos maternos contra a...
Aguiar, Gonçalo; Rocha, Carolina; Spínola, Ana; Gomes, Diana; Amorim, Manuela; Lamas, Maria Céu; Mota, SandraEnquadramento: A Doença Hemolítica do Feto e Recém-Nascido (DHFRN) é um tipo de anemia hemolítica imune, causada pela incompatibilidade eritrocitária feto-materna decorrente da presença de antigénios eritrocitários distintos. Os antigénios dos sistemas ABO e RH são dos clinicamente mais significativos (1–7). Objetivo: O objetivo deste projeto foi realizar um estudo observacional descritivo transversal pa...
Development of a stable melanoma dual reporter cell line expressing Luciferase ...
Aguiar, Gonçalo; Torres, Sílvia; Prudêncio, Cristina; Soares, Raquel; Coelho, Pedro; Prudêncio, Cristina; Coelho, PedroMelanoma is the most aggressive and lethal form of skin cancer, with a high risk of metastatic spread. Obesity is recognized as a risk factor for various types of cancer. However, regarding melanoma, this association remains controversial. Obesity might act as a double-edged sword in melanoma, promoting primary tumour growth but at the same time limiting metastatic spread - the "obesity paradox”. Herein, we aim...
Vascular dysfunction in adipose tissue: Its impact on type 2 diabetes and cancer
Silva, Daniela Rosendo; Aguiar, Gonçalo; Luís, Carla; Soares, Raquel; Coelho, Pedro; Coelho, PedroThe overgrowth of adipose tissue is a major trigger for the development of other metabolic disorders, like insulin resistance, hypertension, type 2 diabetes, cardiovascular disease, and cancer. Among the causes of this association lies the fact that increased adiposity is accompanied by a nonfunctioning vascular component. Accordingly, vascular dysfunction within the adipose tissue is common in obesity and asso...
Effect of umbilical cord mesenchymal stem cells secretome in melanoma
Accioly, Gustavo; Aguiar, Gonçalo; Areal, Lara; Costa, Pedro; Coelho, Pedro; Gomes, AndreiaMelanoma of the skin is one of the most prominent and fastest growing malignancies. More than 300 thousand diagnosed cases and 57 thousand deaths in 2020 worldwide and roughly 517 thousand cases of were registered during the 2015-2020 period. Melanoma is generally regarded as an aggressive and unpredictable cancer whose conventional therapies, such as local excision, chemotherapy and immunotherapy, have encount...