2 documents found, page 1 of 1
Ring-Fused meso-Tetraarylchlorins as Auspicious PDT Sensitizers: Synthesis, Str...
Laranjo, Mafalda; Pereira, Nelson A. M.; Oliveira, Andreia S. R.; Aguiar, Márcia Campos; Brites, Gonçalo Sousa; Nascimento, Bruno F. O.Novel 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-fused meso-tetraarylchlorins, with different degrees of hydrophilicity (with methyl ester, hydroxymethyl, and carboxylic acid moieties), have been synthesized and their photophysical characterization as well as in vitro photocytotoxicity assessment against human melanoma and esophageal and bladder carcinomas was carried out. An integrated analysis of the photosens...
Platinum(II) ring-fused chlorins as efficient theranostic agents: Dyes for tumo...
Laranjo, Mafalda; Aguiar, Márcia Campos; Pereira, Nelson A. M.; Brites, Gonçalo; Nascimento, Bruno F. O.; Brito, Ana F.; Casalta-Lopes, JoãoThe discovery of Pt-chlorin-type theranostic agents is described. Luminescent Pt(II) 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-fused chlorins, with different degrees of hydrophilicity, have been synthesized and their in vitro photocytotoxicity against human melanoma, oesophageal and bladder carcinomas was studied. A di(hydroxymethyl)-substituted chlorin was identified as a privileged molecule to explore imaging...