OxfordNanoporeTechnologiesfortechnicalsupportandQIAGENforsupport of the ZIBRA-2 (Zika in Brazil Real Time Analyses-Second Round)project with reagents and equipment. This work was supported by Decit/SCTIE/MoH and CNPq (440685/2016-8 and 440856/2016-7); by CAPES(88887.130716/2016-00, 88881.130825/2016-00, and 88887.130823/2016-00); by the European Union (EU) Horizon 2020 Programme through ZIKAlliance(PRES-005-FEX...
We conducted the genome sequencing and analysis of the first confirmed COVID-19 infections in Brazil. Rapid sequencing coupled with phylogenetic analyses in the context of travel history corroborate multiple independent importations from Italy and local spread during the initial stage of COVID-19 transmission in Brazil.
Euphorbia umbellata (E. umbellata) belongs to Euphorbiaceae family, popularly known as Janauba, and its latex contains a combination of phorbol esters with biological activities described to different cellular protein kinase C (PKC) isoforms. Here, we identified deoxi-phorbol esters present in E. umbellata latex alcoholic extract that are able to increase HIV transcription and reactivate virus from latency mode...