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Management of tandem occlusions in acute ischaemic stroke
Duarte, João; Morais, Mariana B.; Fragata, Isabel; Aguiar de Sousa, DianaIntra- and extracranial tandem occlusions (TOCs) in acute ischaemic stroke (AIS) are defined by the coexistence of an intracranial anterior or posterior circulation large vessel occlusion together with an ipsilateral extracranial occlusion or significant stenosis in the corresponding proximal vascular axis. They represent a distinct subgroup of AIS requiring tailored diagnostic and therapeutic strategies and ar...
Enhancing Risk Prediction for Cerebral Venous Thrombosis: Evaluation of an Inte...
Dahl, Iselin T Syberg; Dhami, Sanpreet K G; Aguiar de Sousa, Diana; Nakken, Ola; Zarnovicky, Svetozar; Faiz, Kashif Waqar; Sandset, Else CharlotteBackground: Diagnosing cerebral venous thrombosis (CVT) is challenging due to varied symptoms. Computed tomography venography (CTV) or magnetic resonance venography (MRV) are the gold standard, but resource-demanding with potential side effects. We evaluated the diagnostic properties of a previously proposed CVT probability score combined with D-dimer levels in detecting CVT. Methods: Medical records of consecu...
External Validation of the SINCALC Score for Outcomes Following Cerebral Venous...
Klein, Piers; Shu, Liqi; Lindgren, Erik; de Winter, Maria A; Siegler, James E; Simpkins, Alexis N; Omran, Satareh Salehi; Heldner, Mirjam RObjectives: Prognostication for cerebral venous thrombosis (CVT) remains difficult. We sought to validate the SI2NCAL2C score in an international cohort. Materials and methods: The SI2NCAL2C score was originally developed to predict poor outcome (modified Rankin Scale (mRS) 3-6) at 6 months, and mortality at 30 days and 1 year using data from the International CVT Consortium. The SI2NCAL2C score uses 9 variable...
Acute Symptomatic Seizures in Patients with Recurrent Ischemic Stroke: A Multic...
Leal Rato, Miguel; Schön, Miguel; Zafra, Maria Paula; Aguiar de Sousa, Diana; Pinho E Melo, Teresa; Franco, Ana Catarina; Peralta, Ana RitaObjective: Epileptic seizures occur frequently after stroke due to changes in brain function and structure, and up to around 10% of stroke patients experience stroke recurrence in the first year. We aimed to establish the risk of acute symptomatic seizures in patients with recurrent stroke. Methods: Retrospective cohort study including consecutive admissions to a Stroke Unit due to acute ischemic stroke, during...
Cerebral Venous Sinus Thrombosis in Traumatic Brain Injury: a Systematic Review...
Netteland, Dag Ferner; Sandset, Else Charlotte; Mejlænder-Evjensvold, Magnus; Aarhus, Mads; Jeppesen, Elisabeth; Aguiar de Sousa, Diana; Helseth, EirikObjective: Cerebral venous sinus thrombosis (CVST) is increasingly being recognized in the setting of traumatic brain injury (TBI), but its effect on TBI patients and its management remains uncertain. Here, we systematically review the currently available evidence on the complications, effect on mortality and the diagnostic and therapeutic management and follow-up of CVST in the setting of TBI. Methods: Key cli...
Consensus Protocol for the Treatment of Super-Refractory Status Epilepticus
Gomes, Daniel; Pimentel, José; Bentes, Carla; Aguiar de Sousa, Diana; Antunes, Ana Patrícia; Alvarez, António; Silva, Zélia Costa eIntroduction: Super-refractory status epilepticus is defined as status epilepticus that persists or recurs 24 hours after anaesthetic therapy onset or after its withdrawal. It is mostly found in intensive care units and carries high mortality but good long-term prognosis for those who survive. In contrast with the initial phases of status epilepticus, treatment lacks strong scientific evidence and is mostly der...