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Metabolism-Targeted Therapy in NSCLC - A New Theranostics Inhalation Approach U...

Mendes, Cindy; Martins, Filipa; Granja, Sara; Gonçalves, Joana; Barros, Hélio; Casimiro, Teresa; Aguiar-Ricardo, Ana; Silva, Fernanda; Abreu, Bruna

Lung cancer is one of the most lethal cancers globally, primarily due to delayed diagnosis and lack of specific and effective therapy. Increased lactate production and consumption, along with cysteine metabolic reliance, are features identified in NSCLC in our recent studies. Cancer metabolic remodeling leads to excessive ROS production, triggering oxidative stress, promoting angiogenesis, causing cellular and ...


Global Women’s Breakfast (GWB): #UnidaspelaQuímica

Aguiar-Ricardo, Ana; Alves, Arminda; Antunes, M. Cristina; Batalha, Filipa; Oliveira Brett, Ana Maria; Camões, Filomena; Cardoso, Ana L.

Global Women’s Breakfast (GWB): #BoundbyChemistry. Global Women’s Breakfast is an initiative of the International Union of Pure and Applied Chemistry, aiming to give women scientists, from all over the world, the opportunity to know each other, communicating virtually and sharing their experiences. Many countries joined this initiative and Portugal was not an exception, with its participation already at the fir...


Antimicrobial activity of new green-functionalized oxazoline-based oligomers ag...

Martins, Celso; Correia, Vanessa G.; Aguiar-Ricardo, Ana; Cunha, Ângela; Moutinho, Maria Guilhermina M.

"Background: The search for new antimicrobial compounds able to overcome the global issue of microbial resistance to antibiotics is a priority worldwide. Moreover, several commensal microorganisms have been increasingly associated to opportunistic microbial infections. Having previously disclosed the green synthesis and preliminary characterization of the oligomers [linear oligo(ethylenimine) hydrochloride and ...


Antimicrobial activity of new green-functionalized oxazoline-based oligomers ag...

Martins, Celso; Correia, Vanessa G.; Aguiar-Ricardo, Ana; Cunha, Ângela; Moutinho, Maria Guilhermina M.

Background: The search for new antimicrobial compounds able to overcome the global issue of microbial resistance to antibiotics is a priority worldwide. Moreover, several commensal microorganisms have been increasingly associated to opportunistic microbial infections. Having previously disclosed the green synthesis and preliminary characterization of the oligomers [linear oligo(ethylenimine) hydrochloride and o...


Acoustic determination of thermophysical properties and critical parameters for...

Ribeiro, Nuno; Costa, Tânia; Aguiar-Ricardo, Ana; Esperança, José M. S. S.; Pires, Pedro F.; Guedes, Henrique J. R.

The thermophysical properties and critical parameters for the alternative refrigerant R410A (a near azeotropic refrigerant mixture containing difluoromethane (R32) and pentafluoroethane (R125) (50 wt % of each)) were investigated using two different acoustic techniques. The critical behavior of the system xCO2 + (1 - x)R410A was also investigated. Experimental data of speed of sound in liquid R410A from (253 to...


Acoustic determination of thermophysical properties and critical parameters for...

Esperança, José M. S. S.; Pires, Pedro F.; Guedes, Henrique J. R.; Ribeiro, Nuno; Costa, Tânia; Aguiar-Ricardo, Ana

The thermophysical properties and critical parameters for the alternative refrigerant R404A (52 wt % of 1,1,1- trifluoroethane (R143a) + 44 wt % of pentafluoroethane (R125) + 4 wt % of 1,1,1,2-tetrafluoroethane (R134a)) were investigated using two different acoustic techniques. The critical behavior of the system xCO2 + (1 - x)R404A was also investigated. Experimental data of speed of sound in liquid R404A from...


Acoustic determination of thermophysical properties and critical parameters for...

Esperança, José M. S. S.; Pires, Pedro F.; Guedes, Henrique J. R.; Ribeiro, Nuno; Costa, Tânia; Aguiar-Ricardo, Ana

The thermophysical properties and critical parameters for the alternative refrigerant (51 wt % of 1,1,1-trifluoroethane (R143a) + 49 wt % of pentafluoroethane (R125))svery close to the composition of R507 (50 wt % of each mixture component)swere investigated using two different acoustic techniques. The critical behavior of the system xCO2 + (1 - x)(51 wt % R143a + 49 wt % R125) was also investigated. Experiment...


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