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Regulation of Bax/mitochondria interaction by AKT
Simonyan, Lilit; Renault, Thibaud T.; Novais, Maria João da Costa; Sousa, Maria João; Côrte-Real, Manuela; Camougrand, Nadine; Gonzalez, CécileBax-dependent mitochondrial permeabilization during apoptosis is controlled by multiple factors, including the phosphorylation by the protein kinase AKT. We used the heterologous co-expression of human Bax and AKT1 in yeast to investigate how the kinase modulates the different steps underlying Bax activation. We found that AKT activated Bax and increased its cellular content. Both effects were dependent on Ser1...
What yeast can tell us about how cells commit suicide?
Chaves, S. R.; Coutinho, Clara Pereira; Marques, Carolina; Rodrigues, Andreia; Salin, Bénédict; Alves, Sara Cristina Sequeira; Silva, Rui; Gerós, H.Multicellular organisms developed a complex system to balance cell proliferation and cell death in order to guarantee correct embryonic development and tissue homeostasis. Failure of cells to undergo programmed cell death (PCD) can potentially lead to severe diseases, including neural degeneration, autoimmunity and cancer. Identifying the molecules involved in PCD and understanding the regulation of the process...
Vacuole-mitochondrial crosstalk during apoptosis induced by acetic acid in yeast
Chaves, S. R.; Coutinho, Clara Pereira; Marques, Carolina; Rodrigues, Andreia; Salin, Bénédict; Alves, Sara Cristina Sequeira; Silva, Rui; Gerós, H.