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Content validation of a new measure of patient-reported barriers to antiretrovi...

Engler, K; Vicente, S; Mate, K; Lessard, D; Ahmed, S; Lacombe, K; Lebouche, B

Background Over a third of people living with HIV (PLHIV) have suboptimal adherence to antiretroviral therapy (ART). Measures of barriers to ART adherence often lack comprehensiveness. To help manage ART adherence barriers in HIV care, we are developing a new patient-reported outcome measure (PROM) of these barriers (the I-Score). Methods We assessed the content validity of 100 items (distinct barriers) to reta...


Global, regional, and national age-sex-specific mortality for 282 causes of dea...

Roth, GA; Abate, D; Abate, KH; Abay, SM; Abbafati, C; Abbasi, N; Abbastabar, H; Abd-Allah, L; Abdela, J; Abdelalim, A; Abdollahpour, I; Abdulkader, RS

Background Global development goals increasingly rely on country-specific estimates for benchmarking a nation's progress. To meet this need, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 estimated global, regional, national, and, for selected locations, subnational cause-specific mortality beginning in the year 1980. Here we report an update to that study, making use of newly availa...


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