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Long-Term Growth in Phenylketonuria: A Systematic Review and Meta-Analysis

Ilgaz, Fatma; Pinto, Alex; Gökmen-Özel, Hülya; Rocha, Júlio César; van Dam, Esther; Ahring, Kirsten; Bélanger-Quintana, Amaya; Dokoupil, Katharina

There is an ongoing debate regarding the impact of phenylketonuria (PKU) and its treatment on growth. To date, evidence from studies is inconsistent, and data on the whole developmental period is limited. The primary aim of this systematic review was to investigate the effects of a phenylalanine (Phe)-restricted diet on long-term growth in patients with PKU. Four electronic databases were searched for articles ...


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