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Right ventricular to pulmonary artery coupling and prognosis in transthyretin c...

Meucci, Maria Chiara; Laenens, Dorien; Lillo, Rosa; Lombardo, Antonella; Burzotta, Francesco; Stassen, Jan; Debonnaire, Philippe; Claeys, Mathias


Prevalence and prognostic implications of moderate or severe mitral regurgitati...

Butcher, Steele C.; Prevedello, Francesca; Fortuni, Federico; Kong, William K. F.; Singh, Gurpreet K.; Ng, Arnold C. T.; Perry, Rebecca; Poh, Kian Keong

Background: Significant (moderate or greater) mitral regurgitation (MR) could augment the hemodynamic effects of aortic valvular disease in patients with bicuspid aortic valve (BAV), imposing a greater hemodynamic burden on the left ventricle and atrium, possibly culminating in a faster onset of left ventricular dilation and/or symptoms. The aim of this study was to determine the prevalence and prognostic impli...


Left ventricular remodelling in bicuspid aortic valve disease

Butcher, Steele C; Pio, Stephan M; Kong, William K F; Singh, Gurpreet K; Ng, Arnold C T; Perry, Rebecca; Sia, Ching-Hui; Poh, Kian Keong

Aims: Characterization of left ventricular (LV) geometric pattern and LV mass could provide an important insight into the pathophysiological adaptations of the LV to pressure and/or volume overload in patients with bicuspid aortic valve (BAV) and significant (≥moderate) aortic valve (AV) disease. This study aimed to characterize LV remodelling and its prognostic impact in patients with BAV according to the pred...


Prognostic implications of left atrial dilation in aortic regurgitation due to ...

Butcher, Steele C.; Fortuni, Federico; Kong, William; Vollema, E Mara; Prevedello, Francesca; Perry, Rebecca; Ng, Arnold Chin Tse; Poh, Kian Keong

Objective: To investigate the prognostic value of left atrial volume index (LAVI) in patients with moderate to severe aortic regurgitation (AR) and bicuspid aortic valve (BAV). Methods: 554 individuals (45 (IQR 33-57) years, 80% male) with BAV and moderate or severe AR were selected from an international, multicentre registry. The association between LAVI and the combined endpoint of all-cause mortality or aort...


Prognostic implications of left ventricular global longitudinal strain in patie...

Kong, William K F; Vollema, E. Mara; Prevedello, Francesca; Perry, Rebecca; Ng, Arnold C. T.; Poh, Kian Keong; Almeida, Ana G.; González, Ariana

Aims: In patients with bicuspid aortic valve (BAV) and preserved left ventricular (LV) ejection fraction (EF), the frequency of impaired LV global longitudinal strain (GLS) and its prognostic implications are unknown. The present study evaluated the proportion and prognostic value of impaired LV GLS in patients with BAV and preserved LVEF. Methods and results: Five hundred and thirteen patients (68% men; mean a...


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