5 documents found, page 1 of 1
Deletion of codY impairs Staphylococcus epidermidis biofilm formation, generati...
Lopes, Nathalie; Pereira, Renato B; Correia, Alexandra; Vilanova, Manuel; Cerca, Nuno; França, Ângela Maria Oliveira SousaIntroduction. Staphylococcus epidermidis biofilms are one of the major causes of bloodstream infections related to the use of medical devices. The diagnosis of these infections is challenging, delaying their treatment and resulting in increased morbidity and mortality rates. As such, it is urgent to characterize the mechanisms employed by this bacterium to endure antibiotic treatments and the response of the ho...
Thymbra capitata essential oil has a significant antimicrobial activity against...
Almeida, Luciana; Lopes, Nathalie; Gaio, Vânia Silva; Cavaleiro, Carlos; Salgueiro, Lígia; Silva, Vanessa; Poeta, Patrícia; Cerca, NunoAbstract Methicillin-resistant Staphylococcus aureus (MRSA) is a multidrug-resistant opportunistic pathogen with a great ability to form biofilms. Herein, the antimicrobial potential of Thymbra capitata essential oil (EO) against MRSA biofilms was investigated. The determination of the minimum inhibitory concentration (MIC) and the minimum lethal concentration (MLC) of the T. capitata EO was first investigated ...
codY and pdhA expression is induced in Staphylococcus epidermidis biofilm and p...
Gaio, Vania; Lopes, Nathalie; Cerca, Nuno; França, Ângela Maria Oliveira SousaStaphylococcus epidermidis biofilm cells can enter a physiological state known as viable but non-culturable (VBNC), where, despite being alive, they do not grow in conventional laboratory media. As such, the presence of VBNC cells impacts the diagnosis of S. epidermidis biofilm-associated infections. Previous transcriptomics analysis of S. epidermidis strain 9142 biofilms with higher proportions of VBNC cells s...
Virulence factors in coagulase-negative staphylococci
França, Ângela Maria Oliveira Sousa; Gaio, Vânia Silva; Lopes, Nathalie; Melo, Luís Daniel RodriguesCoagulase-negative staphylococci (CoNS) have emerged as major pathogens in healthcare-associated facilities, being S. epidermidis, S. haemolyticus and, more recently, S. lugdunensis, the most clinically relevant species. Despite being less virulent than the well-studied pathogen S. aureus, the number of CoNS strains sequenced is constantly increasing and, with that, the number of virulence factors identified in...
Isolation of clinical strains of Staphylococcus epidermidis from a Portuguese h...
Freitas, Ana Isabel Costa; Lopes, Nathalie; Ramos, H.; Vasconcelos, C.; Vilanova, Manuel; Cerca, NunoStaphylococcus epidermidis has been documented as an emergent pathogen responsible for many healthcareassociated infections (HAIs). These infections are an increasing cause of major concern not only due to the high distribution of methicillin resistance, but also due to their ability to form biofilm, which increases their persistence, impairs patient’s quality of life and leads to failed treatment and extra cos...