3 documents found, page 1 of 1
Bronchial-pulmonary adenocarcinoma subtyping relates with different molecular p...
Sousa, V; Bastos, B; Silva, M; Alarcão, AM; Carvalho, LLung cancer is one of the most common cancers in the world with a high mortality rate. We analyzed 45 surgical samples of the adenocarcinoma, 13 with lymph node metastasis. APC, BCL2, chromogranin A, CK 5/6/18 (LP34), CK20, CK7, cyclin D1, EGFR, ERCC1, HER2, Ki67, LRP, MRP, P53, RB and TTF1 expressions were evaluated by immunohistochemistry (IHC). Higher Ki67, APC, ERCC1 expressions and lower TTF1 expression we...
Lung adenocarcinoma: Sustained subtyping with immunohistochemistry and EGFR, HE...
Sousa, V; Rodrigues, C; Silva, M; Alarcão, AM; Carvalho, LPulmonary adenocarcinomas are still in the process of achieving morphological, immunohistochemical and genetic standardization. The ATS/ERS/IASLC proposed classification for lung adenocarcinomas supports the value of the identification of histological patterns, specifically in biopsies. Thirty pulmonary adenocarcinomas were subjected to immunohistochemical study (CK7, CK5, 6, 18, CK20, TTF1, CD56, HER2, EGFR an...
EGFR/erB-1, HER2/erB-2, CK7, LP34, Ki67 and P53 expression in preneoplastic les...
Sousa, V; Espírito Santo, J; Silva, M; Cabral, T; Alarcão, AM; Gomes, A; Couceiro, P; Carvalho, LA prognostic interpretation of preneoplastic lesions would have impact in bronchial carcinoma early diagnosis and through the study of Erb-B family receptors as they have an important role in lung carcinogenesis. The existence of drugs as tyrosine kinase inhibitors stressed the importance of studying gene alterations for selected chemoprevention schemes and characterization of carcinogenesis. Bronchial preneopl...