6 documents found, page 1 of 1
Nucleolin Overexpression Predicts Patient Prognosis While Providing a Framework...
Fernandes, Ângela Valério; Fonseca, Nuno A.; Gonçalves, Nélio; Cruz, Ana F.; Pereira, Marta I.; Gregório, Ana C.; Moura, Vera; Ladeirinha, Ana F.Notwithstanding the advances in the treatment of lung cancer with immune checkpoint inhibitors, the high percentage of non-responders supports the development of novel anticancer treatments. Herein, the expression of the onco-target nucleolin in patient-derived pulmonary carcinomas was characterized, along with the assessment of its potential as a therapeutic target. The clinical prognostic value of nucleolin f...
Clinical performance evaluation of the Idylla™ EGFR Mutation Test on formalin-f...
Delgado-García, Mercedes; Weynand, Birgit; Gómez-Izquierdo, Lourdes; Hernández, María José; Blanco, Ángela María; Varela, Mar; Matias-Guiu, XavierBackground: Detection of epidermal growth factor receptor (EGFR) mutations in exons 18–21 is recommended in all patients with advanced Non-small-cell lung carcinoma due to the demonstrated efficiency of the standard therapy with tyrosine kinase inhibitors in EGFR-mutated patients. Therefore, choosing a suitable technique to test EGFR mutational status is crucial to warrant a valid result in a short turnaround t...
Prevalence and characteristics of Epstein-Barr virus-associated gastric carcino...
Nogueira, Célia; Mota, Marta; Gradiz, Rui; Cipriano, Maria Augusta; Caramelo, Francisco; Cruz, Hugo; Alarcão, Ana; Castro-Sousa, FranciscoBackground: Gastric cancer (GC) is one of the most common malignant tumors of the digestive tract and is the third leading cause of cancer death worldwide. Epstein–Barr virus (EBV) has been associated with approximately 10% of the total cases of gastric carcinomas. No previous study has analyzed the prevalence of EBV infection in gastric cancer of the Portuguese population. Methods: In the present study, we hav...
Association Between IL-4 and IL-6 Expression Variants and Gastric Cancer Among ...
Sampaio, Ana Maria; Balseiro, Sandra Caramujo; Silva, Maria Reis; Alarcão, Ana; d'Aguiar, Maria João; Ferreira, Teresa; Carvalho, L.Multiple studies have reported strong associations between Helicobacter pylori (Hp) inflammation and gastric cancer (GC) development. Altered expressions of pro/anti-inflammatory cytokines have a crucial role in Hp and GC proliferation. Although there are many studies related to cytokines polymorphisms involvement in GC risk, the role of Interleukin-4 (IL-4) and Interleukin-6 (IL-6) in gastric inflammation proc...
Deficient production of reactive oxygen species leads to severe chronic DSS-ind...
Rodrigues-Sousa, Tiago; Ladeirinha, Ana Filipa Ferreira; Santiago, Ana Raquel; Carvalheiro, Helena; Raposo, Bruno; Alarcão, Ana; Cabrita, AntónioBackground: Colitis is a common clinical complication in chronic granulomatous disease (CGD), a primary immunodeficiency caused by impaired oxidative burst. Existing experimental data from NADPH-oxidase knockout mice propose contradictory roles for the involvement of reactive oxygen species in colitis chronicity and severity. Since genetically controlled mice with a point-mutation in the Ncf1 gene are susceptib...
Carcinoma epidermóide do pulmão: Polissomia e amplificação do cromossoma 7 e do...
Couceiro, Patrícia; Sousa, Vítor; Alarcão, Ana; Silva, Maria; Carvalho, LinaO receptor do factor de crescimento epidérmico (EGFR) está sobreexpresso na maioria dos carcinomas do pulmão de não pequenas células (CPNPC) e é um dos principais alvos específicos dos inibidores da tirosina cinase (TKI) utilizados para o tratamento do CPNPC avançado. Apesar disto, há um considerável número de factores biológicos que também estão associados à resposta dos EGFR-TKIs. Este estudo teve como princi...