5 documents found, page 1 of 1
Evaluation of Tissue and Circulating miR-21 as Potential Biomarker of Response ...
Ourô, Susana; Mourato, Cláudia; Ferreira, Marisa P.; Albergaria, Diogo; Cardador, André; Castro, Rui E.; Maio, Rui; Rodrigues, Cecília M. P.Response to chemoradiotherapy (CRT) in patients with locally advanced rectal cancer (RC) is quite variable and it is urgent to find predictive biomarkers of response. We investigated miR-21 as tissue and plasma biomarker of response to CRT in a prospective cohort of RC patients; The expression of miR-21 was analyzed in pre- and post-CRT rectal tissue and plasma in 37 patients with RC. Two groups were defined: P...
Potential of miR-21 to Predict Incomplete Response to Chemoradiotherapy in Rect...
Ourô, Susana; Mourato, Cláudia; Velho, Sónia; Cardador, André; Ferreira, Marisa P.; Albergaria, Diogo; Castro, Rui E.; Maio, RuiBackground: Patients with locally advanced rectal adenocarcinoma (LARC) are treated with neoadjuvant chemoradiotherapy (CRT). However, biomarkers for patient selection are lacking, and the association between miRNA expression and treatment response and oncological outcomes is unclear. Objectives: To investigate miRNAs as predictors of response to neoadjuvant CRT and its association with oncological outcomes. Me...
MORESTIN SYNDROME: BEYOND THORACIC TRAUMA
Watts Soares, Adriana; Veiga Oliveira, Paulo; Lopes, Beatriz; Albergaria, Diogo; Ourô, Susana; Maio, RuiMorestin syndrome (MS) is a rare clinical manifestation consequent to an acute compression trauma to the thorax. In such an event, the sudden elevated pressure that happens to the airway and the rapid and retrograde blood flow results in capillary rupture in the head and neck vessel territory. This case reports a car accident victim that was dragged by a truck down a road with closed thoracic trauma resulting i...
HELICOBACTER PYLORI AND THE ATHEROGENIC PROCESS IN CARDIOVASCULAR DISEASE
Carvalho, Nuno; Cóias, Ana; Coelho, Hélder; Marcelino, Gisela; Albergaria, Diogo; Ferreira, Maria José; Brito, Maria José; Corte Real, JoãoBackground: Conventional risk factors do not explain completely the atherogenic process. Chronic Helicobacter pylori (HP) infection may cause arterial inflammation and has been epidemiologically linked to the occurrence of atherosclerosis. Studies about the association of HP infection with peripheral arterial disease are limited. Objective: Evaluate the presence of HP using a monoclonal antibody anti-HP in the ...
Neutrophil-to-eosinophil ratio and c-reactive protein are predictors of surgery...
Marcelino, Gisela; Carvalho, Nuno; Oliveira, Gabriel; Marialva, Celso; Campanha, Rafaela; Albergaria, Diogo; Santos, Carlos; Lebre, RuiBackground: Patients with acute diverticulitis (AD) and Hinchey<III may also need surgery. Therefore, as other markers are needed to help deciding which patients should be operated on, we tried to test the value of the C-reactive protein (CRP) and of blood cell count (and their ratios). Methods: Retrospective chart review of patients admitted to our surgical department between 2009 and 2011 with the diagnosi...