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Prognostic impact of left ventricular reverse remodeling after surgical aortic ...

Publisher Copyright: © The Author(s) 2025.; Surgical aortic valve replacement (SAVR) is the treatment of choice for young patients with severe aortic stenosis (AS). Left ventricular (LV) reverse remodeling (RR) after surgery is expected to occur, even though its definition is largely heterogenous and ill-defined. However, LV RR not always occurs following afterload relief, and such may impact the prognosis. Sin...

Factor XI Inhibitors

Anticoagulation therapy has undergone significant evolution, marked by the emergence of direct oral anticoagulants with distinct advantages. Despite these advancements, challenges persist in managing residual thrombotic and bleeding risks, particularly among vulnerable populations. The pursuit of alternative drugs has honed in on factor XI/XIa inhibitors. This comprehensive review delves into several key aspect...

Cardiac magnetic resonance patterns of left ventricular remodeling in patients ...

Publisher Copyright: © The Author(s) 2024.; Left ventricular (LV) hypertrophy is a common finding in patients with severe aortic stenosis (AS). Cardiac magnetic resonance (CMR) is the gold-standard technique to evaluate LV remodeling. Our aim was to assess the prevalence and describe the patterns of LV adaptation in AS patients before and after surgical aortic valve replacement (AVR). Prospective study of 130 c...

Perceptions of cardiology, professional preferences and impact on career choice...

Introduction and Objectives: Cardiology has not been seen as an attractive specialty, and women have avoided it for many years. Some surveys have been performed in other countries, but in Portugal, the situation is largely unknown. Methods: An online survey on perceptions of cardiology and professional preferences was sent to 1371 members of the Portuguese Society of Cardiology, of whom 18.2% completed the surv...

Histopathological myocardial changes in patients with severe aortic stenosis re...

UNLABELLED: Myocardial fibrosis (MF) takes part in left ventricular (LV) remodeling in patients with aortic stenosis (AS), driving the transition from hypertrophy to heart failure. The structural changes that occur in this transition are not fully enlightened. AIM: to describe histopathology changes at endomyocardial biopsy (EMB) in patients with severe AS referred to surgical aortic valve replacement (AVR); to...

Prevalence and significance of relative apical sparing in aortic stenosis

AIMS: This study aims to assess the prevalence of relative apical sparing pattern (RASP) in patients with severe symptomatic aortic stenosis (AS), referred for surgical aortic valve replacement (AVR), to evaluate its significance, possible relation to amyloid deposition, and persistence after surgery. METHODS AND RESULTS: Prospective study of 150 consecutive patients [age 73 (interquartile range: 68-77), 51% wo...

Is myocardial fibrosis appropriately assessed by calibrated and 2D strain deriv...

© 2023. BioMed Central Ltd., part of Springer Nature.; AIMS: Increased collagen content of the myocardium modifies tissue reflectivity and integrated backscatter (IBS) indexes are suggested as markers of myocardial fibrosis (MF). We sought to assess the correlation between calibrated (c) IBS and bidimensional (2D) strain derived IBS with left ventricular (LV) MF in patients with severe aortic stenosis (AS). MET...

Parameters of the mitral apparatus in patients with ischemic and nonischemic di...

Publisher Copyright: © The Author(s) 2023.; The mitral valve apparatus is a complex structure consisting of several coordinating components: the annulus, two leaflets, the chordae tendineae, and the papillary muscles. Due to the intricate interplay between the mitral valve and the left ventricle, a disease of the latter may influence the normal function of the former. As a consequence, valve insufficiency may a...

An Incidental Finding of a Cardiac Sarcoma

Achieving higher efficacy without compromising safety with factor XI inhibitors...

Publisher Copyright: © 2022 The Authors. Journal of Thrombosis and Haemostasis published by Wiley Periodicals LLC on behalf of International Society on Thrombosis and Haemostasis.; Background: In recent years, many important advances have been seen in anticoagulation therapy. However, bleeding risk is still a major concern. Factor XI (FXI) inhibition has emerged as a potential advantageous target to minimize th...