7 documents found, page 1 of 1
High Instantaneous Inhibitory Potential of Bictegravir and the New Spiro-ß-Lact...
Bártolo, Inês; Moranguinho, Inês; Gonçalves, Paloma; Ana Rita Diniz; Borrego, Pedro; Martin, Francisco; Figueiredo, Inês; Gomes, PerpetuaIntegrase inhibitors (INIs) are an important class of drugs for treating HIV-2 infection, given the limited number of drugs active against this virus. While the clinical efficacy of raltegravir and dolutegravir is well established, the clinical efficacy of bictegravir for treating HIV-2 infected patients has not been determined. Little information is available regarding the activity of bictegravir against HIV-2...
In vitro evaluation of novel reverse transcriptase inhibitors TAF (tenofovir al...
Bártolo, Inês; Borrego, Pedro; Gomes, Perpetua; Gonçalves, Maria Fátima; Caixas, Umbelina; Vaz-Pinto, Inês; Taveira, NunoNew antiretroviral drugs are needed to treat HIV-2 infected patients failing therapy. Herein, we evaluate the activity of novel reverse transcriptase inhibitors tenofovir alafenamide (TAF) and OBP-601(2,3-didehydro-3-deoxy-4-ethynylthymidine) against primary isolates from HIV-2 infected patients experiencing virologic failure. TAF and OBP-601 were tested against twelve primary isolates obtained from nine drug-e...
Early infant diagnosis of HIV-1 infection in Luanda, Angola, using a new DNA PC...
Martin, Francisco; Palladino, Claudia; Mateus, Rita; Bolzan, Anna; Gomes, Perpetua; Brito, José; Carvalho, Ana Patrícia; Cardoso, YolandaBackground Early diagnosis and treatment reduces HIV-1-related mortality, morbidity and size of viral reservoirs in infants infected perinatally. Commercial molecular tests enable the early diagnosis of infection in infants but the high cost and low sensitivity with dried blood spots (DBS) limit their use in sub-Saharan Africa. Objectives To develop and validate a sensitive and cheap qualitative proviral DNA PC...
Evolution of the human immunodeficiency virus type 2 envelope in the first year...
Rocha, Cheila; Calado, Rita; Borrego, Pedro; Marcelino, José Maria; Bártolo, Inês; Rosado, Lino; Cavaco-Silva, Patricia; Gomes, PerpetuaBackground Differently from HIV-1, HIV-2 disease progression usually takes decades without antiretroviral therapy and the majority of HIV-2 infected individuals survive as elite controllers with normal CD4+ T cell counts and low or undetectable plasma viral load. Neutralizing antibodies (Nabs) are thought to play a central role in HIV-2 evolution and pathogenesis. However, the dynamic of the Nab response and re...
Origin and epidemiological history of HIV-1 CRF14_BG
Bártolo, Inês; Abecasis, Ana B.; Borrego, Pedro; Barroso, Helena; McCutchan, Francine; Gomes, Perpetua; Camacho, Ricardo; Taveira, NunoBackground CRF14_BG isolates, originally found in Spain, are characterized by CXCR4 tropism and rapid disease progression. This study aimed to identify the origin of CRF14_BG and reconstruct its epidemiological history based on new isolates from Portugal. Methodology/Principal Findings C2V3C3 env gene sequences were obtained from 62 samples collected in 1993–1998 from Portuguese HIV-1 patients. Full-length geno...
Envelope-specific antibody response in HIV-2 infection
Marcelino, Jose Maria; Nilsson, Charlotta; Barroso, Helena; Gomes, Perpetua; Borrego, Pedro; Maltez, Fernando; Rosado, Lino; Doroana, ManuelaObjective: To examine the unspecific and envelope-specific IgA and IgG responses in acute and chronic HIV-2 infection. Methods: Twenty-eight chronically infected adults and two children with perinatal infection were studied. Total plasma concentrations of. - Fundacao para a Ciencia e Tecnologia [POCTI/ESP/48045]. - The present work was supported by Fundacao para a Ciencia e Tecnologia (project POCTI/ESP/48045)....
The role of the humoral immune response in the molecular evolution of the envel...
Borrego, Pedro; Marcelino, Jose Maria; Rocha, Cheila; Doroana, Manuela; Antunes, Francisco; Maltez, Fernando; Gomes, Perpetua; Novo, CarlosBackground: This study was designed to investigate, for the first time, the short-term molecular evolution of the HIV-2 C2, V3 and C3 envelope regions and its association with the immune response. Clonal sequences of the env C2V3C3 region were obtained fr. - Fundacao para a Ciencia e Tecnologia [POCTI/ESP/48045]. - This work was supported by Fundacao para a Ciencia e Tecnologia (project POCTI/ESP/48045). Pedro ...