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Epibatidine: A promising natural alkaloid in health

Salehi, B; Sestito, S; Rapposelli, S; Peron, G; Calina, D; Sharifi-Rad, M; Sharopov, F; Martins, N; Sharifi-Rad, J

Epibatidine is a natural alkaloid that acts at nicotinic acetylcholine receptors (nAChRs). The present review aims to carefully discuss the affinity of epibatidine and its synthetic derivatives, analogues to nAChRs for a4ß2 subtype, pharmacokinetic parameters, and its role in health. Published literature shows a low affinity and lack of binding of epibatidine and its synthetic analogues to plasma proteins, indi...

Date: 2019 | Origin: Repositório Aberto da Universidade do Porto

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